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AdipoGen Life Sciences
Latrunculin B
150
CHF
CHF 150.00
In stock
AG-CN2-0031-C500500 µgCHF 150.00
AG-CN2-0031-M0011 mgCHF 250.00
BULK available!
| Product Details | |
|---|---|
| Synonyms | LAT-B; NSC 339663; LatB |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H29NO5S |
| MW | 395.5 |
| Merck Index | 14: 5378 |
| CAS | 76343-94-7 |
| Source/Host Chemicals | Isolated from Latrunculia magnifica. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Colorless viscous film |
| Solubility | Soluble in DMSO (25mg/ml) or ethanol (25mg/ml). |
| Identity | Determined by 1H-NMR. |
| InChi Key | NSHPHXHGRHSMIK-JRIKCGFMSA-N |
| Smiles | C[C@@H](CC[C@@H](O[C@]([C@@]1([H])NC(SC1)=O)(O)C2)C[C@H]2O3)/C=C\CC/C(C)=C\C3=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable marine toxin [1].
- Disrupts microfilament-mediated processes [2].
- Actin polymerization inhibitor in vitro and in vivo by the formation of a 1:1 complex with monomeric G-actin [1, 2, 3].
- Depolymerizes actin filaments (F-actin) [3].
- Less potent than Latrunculin A (Prod. No. AG-CN2-0027). May have fewer unwanted effects than latrunculin A and may be preferred for short-term studies [4, 5].
- Acts via a different mechanism than cytochalasins.
Product References
- Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells: I. Spector, et al.; Science 219, 493 (1983)
- Latrunculin inhibits the microfilament-mediated processes during fertilization, cleavage and early development in sea urchins and mice: G. Schatten, et al.; Exp. Cell Res. 166, 191 (1986)
- Inhibition of actin polymerization by latrunculin: A: M. Coue, et al.; FEBS Lett. 213, 316 (1987)
- Latrunculins-novel marine macrolides that disrupt microfilament organization and affect cell growth: I. Comparison with cytochalasin D: I. Spector, et al.; Cell Motil. Cytoskeleton 13, 127 (1989)
- Effects of cytochalasin D and latrunculin B on mechanical properties of cells: T. Wakatsuki, et al.; J. Cell. Sci. 114, 1025 (2001)
- RNAi screening identifies the armadillo repeat-containing kinesins responsible for microtubule-dependent nuclear positioning in Physcomitrella patens: T. Miki, et al.; Plant Cell Physiol. 56, 737 (2015)
- Evidence that an unconventional actin can provide essential F-actin function and that a surveillance system monitors F-actin integrity in Chlamydomonas: M. Onishi, et al.; Genetics 202, 977 (2016)
- Cleavage-furrow formation without F-actininChlamydomonas: M. Onishi, et al.; PNAS 117, 18511 (2020)
- Systematic characterization of gene function in the photosynthetic alga Chlamydomonas reinhardtii: F. Fauser, et al.; Nature Genet. ahead of print (2022)
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