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AdipoGen Life Sciences
Resveratrol (synthetic)
35
CHF
CHF 35.00
In stock
AG-CN2-0036-M05050 mgCHF 35.00
AG-CN2-0036-M100100 mgCHF 55.00
AG-CN2-0036-M500500 mgCHF 170.00
| Product Details | |
|---|---|
| Synonyms | trans-3,4’,5-Trihydroxystilbene; trans-Resveratrol; (E)-Resveratrol; 3,4’,5-Stilbenetriol |
| Product Type | Chemical |
| Properties | |
| Formula |
C14H12O3 |
| MW | 228.2 |
| Merck Index | 14: 8158 |
| CAS | 501-36-0 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Off-white powder. |
| Solubility | Soluble in DMSO, ethanol or DMF. Slightly soluble in water or PBS. |
| InChi Key | LUKBXSAWLPMMSZ-OWOJBTEDSA-N |
| Smiles | OC1=CC=C(\C=C\C2=CC(O)=CC(O)=C2)C=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent phenolic antioxidant found in grapes and red wine [1, 19].
- Eicosanoid synthesis and platelet aggregation inhibitor [2].
- Estrogen receptor agonist [3].
- Chemopreventive [4, 15].
- Specific inhibitor of cyclooxygenase-1 (COX-1) [4].
- Anti-inflammatory [4, 21].
- Ribonucleotide reductase and DNA synthesis [5].
- Arrests cell cycle at S/G2 phase [6, 23].
- Anticancer and antiproliferative compound [7, 16].
- Apoptosis inducer [8, 23].
- Protein kinase D inhibitor. Does not inhibit PKC [9].
- Autophagy inducer [10, 23].
- Potent SIRT1 (sirtuin 1) activator [11, 22].
- Neuroprotective [12, 18].
- Adipogenesis inhibitor [13].
- PGC-1α activator [14].
- Sonic hedgehog (Shh) signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity [17].
- Cardioprotective [19, 21].
- Anti-diabetic [20].
- Senescence modulator. Extends lifespan [22].
Product References
- Antioxidant activity of resveratrol in red wine: N.J. Miller & C. Rice-Evans; Clin. Chem. 41, 1789 (1995)
- The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease: C.R. Pace-Asciak, et al.; Clin. Chem. Acta 235, 207 (1995)
- Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor: B.D. Gehm, et al.; PNAS 94, 14138 (1997)
- Cancer chemopreventive activity of resveratrol, a natural product derived from grapes: M. Jang, et al.; Science 275, 218 (1997)
- Resveratrol, a remarkable inhibitor of ribonucleotide reductase: M. Fontecave, et al.; FEBS Lett. 421, 277 (1998)
- Resveratrol arrests the cell division cycle at S/G2 phase transition: F.D. Ragione, et al.; BBRC 250, 53 (1998)
- Antiproliferative effect of synthetic resveratrol on human breast epithelial cells: O.P. Mgbonyebi, et al.; Int. J. Oncol. 12, 865 (1998)
- Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells: J. Dörrie, et al.; Cancer Res. 61, 4731 (2001)
- Inhibition of protein kinase D by resveratrol: R.S. Haworth & M. Avkiran; Biochem. Pharmacol. 62, 1647 (2001)
- Resveratrol-induced autophagocytosis in ovarian cancer cells: A.W. Jr. Opipari, et al.; Cancer Res. 64, 696 (2004)
- Mechanism of Human SIRT1 Activation by Resveratrol: MT. Borra, et al.; J. Biol. Chem. 280, 17187 (2005)
- Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?: P. Saiko, et al.; Mutat. Res. 658, 68 (2008)
- Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes: S. Rayalam, et al.; Phytother. Res. 22, 1367 (2008)
- Resveratrol exerts pharmacological preconditioning by activating PGC-1α: L. Tan, et al.; Med. Hypotheses 71, 664 (2008)
- Resveratrol and chemoprevention: S.K. Goswami & D.K. Das; Cancer Lett. 284, 1 (2009) (Review)
- Resveratrol: Biological and pharmaceutical properties as anticancer molecule: T.C. Hsieh & J.M. Wu; Biofactors 36, 360 (2010) (Review)
- Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer: A. Slusarz, et al.; Cancer Res. 70, 3382 (2010)
- Neuroprotective properties of resveratrol in different neurodegenerative disorders: D. Albani, et al.; Biofactors 36, 370 (2010) (Review)
- Resveratrol: a cardioprotective substance: J.M. Wu & T.C. Hsieh; Ann. N. Y. Acad. Sci. 1215, 16 (2011) (Review)
- Anti-diabetic effects of resveratrol: T. Szkudelski & K. Szkudelska; Ann. N. Y. Acad. Sci. 1215, 34 (2011) (Review)
- Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease: A. Csiszar; Ann. N. Y. Acad. Sci. 1215, 117 (2011) (Review)
- Resveratrol and life extension: B. Agarwal & J.A. Baur; Ann. N. Y. Acad. Sci. 1215, 138 (2011) (Review)
- Resveratrol, a phytochemical inducer of multiple cell death pathways: apoptosis, autophagy and mitotic catastrophe: D. Delmas, et al.; Curr. Med. Chem. 18, 1100 (2011) (Review)
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