AdipoGen Life Sciences

Resveratrol

CHF 35.00
In stock
AG-CN2-0033-M05050 mgCHF 35.00
AG-CN2-0033-M100100 mgCHF 55.00
AG-CN2-0033-M500500 mgCHF 170.00
More Information
Product Details
Synonyms trans-3,4’,5-Trihydroxystilbene; trans-Resveratrol; (E)-Resveratrol; 3,4’,5-Stilbenetriol
Product Type Chemical
Properties
Formula C14H12O3
MW 228.2
Merck Index 14: 8158
CAS 501-36-0
Source/Host Chemicals Isolated from Polygonum cuspidatum.
Purity Chemicals ≥98% (HPLC)
Appearance Off-white to greyish powder.
Solubility Soluble in DMSO, ethanol or DMF. Slightly soluble in water or PBS.
InChi Key LUKBXSAWLPMMSZ-OWOJBTEDSA-N
Smiles OC1=CC=C(\C=C\C2=CC(O)=CC(O)=C2)C=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Potent phenolic antioxidant found in grapes and red wine [1, 19].
  • Eicosanoid synthesis and platelet aggregation inhibitor [2].
  • Estrogen receptor agonist [3].
  • Chemopreventive [4, 15].
  • Specific inhibitor of cyclooxygenase-1 (COX-1) [4].
  • Anti-inflammatory [4, 21].
  • Ribonucleotide reductase and DNA synthesis [5].
  • Arrests cell cycle at S/G2 phase [6, 23].
  • Anticancer and antiproliferative compound [7, 16].
  • Apoptosis inducer [8, 23].
  • Protein kinase D inhibitor. Does not inhibit PKC [9].
  • Autophagy inducer [10, 23].
  • Potent SIRT1 (sirtuin 1) activator [11, 22].
  • Neuroprotective [12, 18].
  • Adipogenesis inhibitor [13].
  • PGC-1α activator [14].
  • Sonic hedgehog (Shh) signaling pathway modulator. Gli1 mRNA expression inhibitor. Downregulates Gli transcriptional activity [17].
  • Cardioprotective [19, 21].
  • Anti-diabetic [20].
  • Senescence modulator. Extends lifespan [22].
  • Inhibitor of NLRP3 inflammasome activation [24].
Product References
  1. Antioxidant activity of resveratrol in red wine: N.J. Miller & C. Rice-Evans; Clin. Chem. 41, 1789 (1995)
  2. The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: implications for protection against coronary heart disease: C.R. Pace-Asciak, et al.; Clin. Chem. Acta 235, 207 (1995)
  3. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor: B.D. Gehm, et al.; PNAS 94, 14138 (1997)
  4. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes: M. Jang, et al.; Science 275, 218 (1997)
  5. Resveratrol, a remarkable inhibitor of ribonucleotide reductase: M. Fontecave, et al.; FEBS Lett. 421, 277 (1998)
  6. Resveratrol arrests the cell division cycle at S/G2 phase transition: F.D. Ragione, et al.; BBRC 250, 53 (1998)
  7. Antiproliferative effect of synthetic resveratrol on human breast epithelial cells: O.P. Mgbonyebi, et al.; Int. J. Oncol. 12, 865 (1998)
  8. Resveratrol induces extensive apoptosis by depolarizing mitochondrial membranes and activating caspase-9 in acute lymphoblastic leukemia cells: J. Dörrie, et al.; Cancer Res. 61, 4731 (2001)
  9. Inhibition of protein kinase D by resveratrol: R.S. Haworth & M. Avkiran; Biochem. Pharmacol. 62, 1647 (2001)
  10. Resveratrol-induced autophagocytosis in ovarian cancer cells: A.W. Jr. Opipari, et al.; Cancer Res. 64, 696 (2004)
  11. Mechanism of Human SIRT1 Activation by Resveratrol: MT. Borra, et al.; J. Biol. Chem. 280, 17187 (2005)
  12. Resveratrol and its analogs: Defense against cancer, coronary disease and neurodegenerative maladies or just a fad?: P. Saiko, et al.; Mutat. Res. 658, 68 (2008)
  13. Resveratrol induces apoptosis and inhibits adipogenesis in 3T3-L1 adipocytes: S. Rayalam, et al.; Phytother. Res. 22, 1367 (2008)
  14. Resveratrol exerts pharmacological preconditioning by activating PGC-1α: L. Tan, et al.; Med. Hypotheses 71, 664 (2008)
  15. Resveratrol and chemoprevention: S.K. Goswami & D.K. Das; Cancer Lett. 284, 1 (2009) (Review)
  16. Resveratrol: Biological and pharmaceutical properties as anticancer molecule: T.C. Hsieh & J.M. Wu; Biofactors 36, 360 (2010) (Review)
  17. Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer: A. Slusarz, et al.; Cancer Res. 70, 3382 (2010)
  18. Neuroprotective properties of resveratrol in different neurodegenerative disorders: D. Albani, et al.; Biofactors 36, 370 (2010) (Review)
  19. Resveratrol: a cardioprotective substance: J.M. Wu & T.C. Hsieh; Ann. N. Y. Acad. Sci. 1215, 16 (2011) (Review)
  20. Anti-diabetic effects of resveratrol: T. Szkudelski & K. Szkudelska; Ann. N. Y. Acad. Sci. 1215, 34 (2011) (Review)
  21. Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease: A. Csiszar; Ann. N. Y. Acad. Sci. 1215, 117 (2011) (Review)
  22. Resveratrol and life extension: B. Agarwal & J.A. Baur; Ann. N. Y. Acad. Sci. 1215, 138 (2011) (Review)
  23. Resveratrol, a phytochemical inducer of multiple cell death pathways: apoptosis, autophagy and mitotic catastrophe: D. Delmas, et al.; Curr. Med. Chem. 18, 1100 (2011) (Review)
  24. Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy: Y.P. Chang, et al.; J. Cell Physiol. 230, 1567 (2015)
  25. Resveratrol ameliorates the cyclosporine-induced vascular and renal impairments: possible impact of the modulation of renin–angiotensin system: S. Bekpinar, et al.; Can. J. Physiol. Pharmacol. 97, 1115 (2019)
© 2017 Adipogen Life Sciences. Pictures: © 2012 Martin Oeggerli. All Rights Reserved.