Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
Podophyllotoxin
45
CHF
CHF 45.00
In stock
AG-CN2-0049-M100100 mgCHF 45.00
AG-CN2-0049-M500500 mgCHF 120.00
| Product Details | |
|---|---|
| Synonyms | Podofilox; NSC 24818; Podophyllinic acid lactone |
| Product Type | Chemical |
| Properties | |
| Formula |
C22H22O8 |
| MW | 414.4 |
| Merck Index | 14: 7546 |
| CAS | 518-28-5 |
| RTECS | LZ2500000 |
| Source/Host Chemicals | Isolated from Podophyllum emodi rhizomes. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in chloroform, acetone, ethyl acetate or ethanol. Insoluble in water. |
| InChi Key | YJGVMLPVUAXIQN-LBXUKJEYSA-N |
| Smiles | [H][C@]12COC(=O)[C@]1([H])C(C1=CC(OC)=C(OC)C(OC)=C1)C1=C(C=C3OCOC3=C1)[C@@H]2O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Hygroscopic. Keep under inert gas. Protect from moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent microtubule assembly inhibitor [1-3].
- Anticancer compound [1-5, 7].
- Cell death inducer [1-5, 7].
- DNA topoisomerase II inhibitor. Cell cycle inhibitor at the metaphase [2, 6, 8].
- Antiviral [3, 4, 9] and antihelminthic [1].
Product References
- VP16-213 and podophyllotoxin. A study on the relationship between chemical structure and biological activity: J.D. Loike; Cancer Chemother. Pharmacol. 7, 103 (1982)
- Antitumor agents. I. DNA topoisomerase II inhibitory activity and the structural relationship of podophyllotoxin derivatives as antitumor agents: T. Terada, et al.; Chem. Pharmacol. Bull. (Tokyo) 40, 2720 (1992)
- Antineoplastic and antiviral activities of podophyllotoxin related lignans: M. Gordaliza, et al.; Arch. Pharmacol. 327, 175 (1994)
- Podophyllotoxin: C. Canel, et al.; Phytochemistry 54, 115 (2000) (Review)
- Antitumor properties of podophyllotoxin and related compounds: M. Gordaliza, et al.; Curr. Pharm. Des. 6, 1811 (2000) (Review)
- Drugs that inhibit tubulin polymerization: the particular case of podophyllotoxin and analogues: S. Desbene & S. Giorgi-Renault; Curr. Med. Chem. Anticancer Agents 2, 71 (2002) (Review)
- Podophyllotoxin derivatives: current synthetic approaches for new anticancer agents: Y. You; Curr. Pharm. Des. 11, 1695 (2005) (Review)
- Camptothecin and podophyllotoxin derivatives: inhibitors of topoisomerase I and II - mechanisms of action, pharmacokinetics and toxicity profile: J.T. Hartmann & H.P. Lipp; Drug Saf. 29, 209 (2006) (Review)
- An evidence-based review of medical and surgical treatments of genital warts: N. Scheinfeld & D.S. Lehman; Dermatol. Online J. 12, 5 (2006)
Related Products
