AdipoGen Life Sciences

Ponasterone A

CHF 70.00
In stock
AG-CN2-0053-M0011 mgCHF 70.00
AG-CN2-0053-M0055 mgCHF 250.00
AG-CN2-0053-M02525 mgCHF 980.00
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Product Details
Synonyms Pon A; 25-Deoxy-20-hydroxyecdysone; 25-Deoxyecdysterone; AI3-44686; 2β,3β,14α,20R,22R-Pentahydroxy-5β-cholest-7-en-6-one
Product Type Chemical


MW 464.6
Merck Index 14: 7588
CAS 13408-56-5
Source/Host Chemicals Semi-synthetic.
Purity Chemicals ≥95% (HPLC)
Appearance White to off-white powder.
Solubility Soluble in acetic acid, ethanol, methanol or DMSO. Insoluble in water.
Identity Identity determined by 1H- and 13C-NMR.
Other Product Data

To prepare a 1mM stock solution (1.1mM) in 100% ethanol: Add 2ml of 100% ethanol to 1mg (2µmol). Gently mix to dissolve the product (5 to 10min.). Do not heat solution to dissolve the product. Store the 1mM stock solution at +4°C or at -20°C.

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Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • A member of the ecdysteroid family.
  • Ecdysone receptor (EcR) agonist.
  • Analog of ecdysone with similar properties to muristerone A.
  • Functional, reliable and economical substitute for muristerone A as an inducer for the ecdysone-inducible mammalian expression system.
  • Induces expression of β-galactosidase to levels similar to those obtained with muristerone A induction.
  • Potent compound for ecdysteroid activity.
  • Insect steroid hormone involved in regulating metamorphosis.
Product References
  1. Extraction of ponasterone A and ecdysterone from podocarpaceae and related plants: S. Imai et al.; Steroids 10, 557 (1967)
  2. Ecdysones and analogs: effects on development and reproduction of insects: W.E. Robbins, et al.; Science 161, 1158 (1968)
  3. The uptake and release of ponasterone A by the Kc cell line of Drosophila melanogaster: C. Beckers, et al.; Mol. Cell. Endocrinol. 17, 51 (1980)
  4. Past and present studies with ponasterones, the first insect molting hormones from plants: K. Nakanishi; Steroids 57, 649 (1992)
  5. Identification of ligands and coligands for the ecdysone-regulated gene switch: E. Saez, et al.; PNAS 97, 14512 (2000)
  6. Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells: C. Rampazzo, et al.; J. Biol. Chem. 275, 5409 (2000)
  7. Sustained mammary gland-directed, ponasterone A-inducible expression in transgenic mice: C. Albanese, et al.; FASEB J. 14, 877 (2000)
  8. The ecdysone inducible gene expression system: unexpected effects of muristerone A and ponasterone A on cytokine signaling in mammalian cells: S. Constantino, et al.; Eur. Cytokine Netw. 12, 365 (2001)
  9. Recent advances in inducible expression in transgenic mice: C. Albanese, et al.; Semin. Cell. Dev. Biol. 13, 129 (2002)
  10. Potent and selective partial ecdysone agonist activity of chromafenozide in Sf9 cells: T. Toya, et al.; BBRC 292, 1087 (2002)
  11. Development of a ponasterone A-inducible gene expression system for application in cultured skeletal muscle cells: Y.Y. Xiao, et al.; Int. J. Biochem. Cell. Biol. 35, 79 (2003)
  12. Development of an in vitro Reporter Gene Assay for Screening the Ecdysone Receptor Agonists in Mysid Crustacean: M. Hirano, et al.; Terrapub 141 (2010)
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