AdipoGen Life Sciences

Muristerone A

CHF 75.00
In stock
AG-CN2-0070-C250250 µgCHF 75.00
AG-CN2-0070-M0011 mgCHF 190.00
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Product Details
Synonyms 2β,3β,5β,11α,14α,20R,22R-Heptahydroxycholest-7-en-6-one
Product Type Chemical
Properties
Formula

C27H44O8

MW 496.6
CAS 38778-30-2
Source/Host Chemicals Isolated from Ipomoea hederacea seeds.
Purity Chemicals ≥95% (HPLC)
Appearance White to off-white solid.
Solubility Soluble in acetic acid, ethanol, methanol or DMSO. Insoluble in water.
Identity Identity determined by 1H-NMR.
Other Product Data

To prepare a 1mM stock solution (1.1mM) in 100% ethanol: Add 2ml of 100% ethanol to 1mg muristerone A (2µmol). Gently mix to dissolve the product (5 to 10min.). Do not heat solution to dissolve the product. Store the 1mM stock solution at +4°C or at -20°C.

InChi Key LRJUYAVTHIEHAI-LDJCFVSYSA-N
Smiles [H][C@@]1(CC[C@@]2(O)C3=CC(=O)[C@]4(O)C[C@@H](O)[C@@H](O)C[C@]4(C)C3[C@H](O)C[C@]12C)[C@@](C)(O)[C@H](O)CCC(C)C
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Potent member of the ecdysteroid family.
  • Ecdysone receptor (EcR) agonist.
  • Analog of ecdysone with similar properties to ponasterone A (Prod. No. AG-CN2-0053).
  • Inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals.
  • Induces apoptosis in cells transfected with wild-type Bax.
  • Induces expression of β-galactosidase.
  • Stimulates Bcl-XL mRNA transcription and inhibits TRAIL- and hFasL-induced apoptosis in RKO cells.
  • Insect steroid hormone involved in regulating metamorphosis, causing a response to G2 cell cycle arrest.
  • Major molting hormone in some insects. Has protective effects in plants.
Product References
  1. Structure of muristerone A, a new phytoecdysone: L. Canonica, et al.; J. C. S. Chem. Commun. 1060 (1972)
  2. New phytoecdysones from kaladana. I. Structure of muristerone A and kaladasterone: L. Canonica, et al.; Gazz. Chim. Ital. 107, 123 (1977)
  3. Characterization and partial purification of the Drosophila Kc cell ecdysteroid receptor: T.M. Landon, et al.; J. Biol. Chem. 263, 4693 (1988)
  4. Ecdysteroid-Dependent Regulation of Genes in Mammalian Cells by a Drosophila Ecdysone Receptor and Chimeric Transactivators: K. Christopherson, et al.; PNAS 89, 6314 (1992)
  5. Ecdysone-inducible gene expression in mammalian cells and transgenic mice: D. No, et al.; PNAS 93, 3346 (1996)
  6. The overexpression of Bax produces cell death upon induction of the mitochondrial permeability transition: J.G. Pastorino, et al.; J. Biol. Chem. 273, 7770 (1998)
  7. Impairment of the proapoptotic activity of Bax by missense mutations found in gastrointestinal cancers: J. Gil, et al.; Cancer Res. 59, 2034 (1999)
  8. Identification of ligands and coligands for the ecdysone-regulated gene switch: E. Saez, et al.; PNAS 97, 14512 (2000)
  9. Ectopic expression of cyclin D1 impairs the proliferation and enhances the apoptosis of a murine lymphoid cell line: F. Duquesne, et al.; Cell Death Differ. 8, 51 (2001)
  10. The ecdysone inducible gene expression system: unexpected effects of muristerone A and ponasterone A on cytokine signaling in mammalian cells: S. Constantino, et al.; Eur. Cytokine Netw. 12, 365 (2001)
  11. Muristerone A-induced nerve growth factor release from genetically engineered human dermal fibroblasts for peripheral nerve tissue engineering:  C.W. Patrick, et al.; Tissue Eng. 7, 303 (2001)
  12. Agonists of an ecdysone-inducible mammalian expression system inhibit Fas-ligand- and TRAIL-induced apoptosis in the human colon carcinoma cell line RKO: I Oehme, et al.;  Cell Death Diff. 13, 189 (2005)
  13. Selected technologies to control genes and their products for experimental and clinical purposes: H.K. Alexander, et al.; Arch. Immunol. Ther. Exp. 55, 139 (2007) (Review)
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