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AdipoGen Life Sciences
Ponasterone A
70
CHF
CHF 70.00
In stock
AG-CN2-0053-M0011 mgCHF 70.00
AG-CN2-0053-M0055 mgCHF 250.00
AG-CN2-0053-M02525 mgCHF 980.00
| Product Details | |
|---|---|
| Synonyms | Pon A; 25-Deoxy-20-hydroxyecdysone; 25-Deoxyecdysterone; AI3-44686; 2β,3β,14α,20R,22R-Pentahydroxy-5β-cholest-7-en-6-one |
| Product Type | Chemical |
| Properties | |
| Formula |
C27H44O6 |
| MW | 464.6 |
| Merck Index | 14: 7588 |
| CAS | 13408-56-5 |
| Source/Host Chemicals | Semi-synthetic. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in acetic acid, ethanol, methanol or DMSO. Insoluble in water. |
| Identity | Identity determined by 1H- and 13C-NMR. |
| Other Product Data |
To prepare a 1mM stock solution (1.1mM) in 100% ethanol: Add 2ml of 100% ethanol to 1mg (2µmol). Gently mix to dissolve the product (5 to 10min.). Do not heat solution to dissolve the product. Store the 1mM stock solution at +4°C or at -20°C. |
| InChi Key | PJYYBCXMCWDUAZ-JJJZTNILSA-N |
| Smiles | [H][C@@]1(CC[C@@]2(O)C3=CC(=O)[C@]4([H])C[C@@H](O)[C@@H](O)C[C@]4(C)[C@@]3([H])CC[C@]12C)[C@@](C)(O)[C@H](O)CCC(C)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- A member of the ecdysteroid family.
- Ecdysone receptor (EcR) agonist.
- Analog of ecdysone with similar properties to muristerone A.
- Functional, reliable and economical substitute for muristerone A as an inducer for the ecdysone-inducible mammalian expression system.
- Induces expression of β-galactosidase to levels similar to those obtained with muristerone A induction.
- Potent compound for ecdysteroid activity.
- Insect steroid hormone involved in regulating metamorphosis.
Product References
- Extraction of ponasterone A and ecdysterone from podocarpaceae and related plants: S. Imai et al.; Steroids 10, 557 (1967)
- Ecdysones and analogs: effects on development and reproduction of insects: W.E. Robbins, et al.; Science 161, 1158 (1968)
- The uptake and release of ponasterone A by the Kc cell line of Drosophila melanogaster: C. Beckers, et al.; Mol. Cell. Endocrinol. 17, 51 (1980)
- Past and present studies with ponasterones, the first insect molting hormones from plants: K. Nakanishi; Steroids 57, 649 (1992)
- Identification of ligands and coligands for the ecdysone-regulated gene switch: E. Saez, et al.; PNAS 97, 14512 (2000)
- Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells: C. Rampazzo, et al.; J. Biol. Chem. 275, 5409 (2000)
- Sustained mammary gland-directed, ponasterone A-inducible expression in transgenic mice: C. Albanese, et al.; FASEB J. 14, 877 (2000)
- The ecdysone inducible gene expression system: unexpected effects of muristerone A and ponasterone A on cytokine signaling in mammalian cells: S. Constantino, et al.; Eur. Cytokine Netw. 12, 365 (2001)
- Recent advances in inducible expression in transgenic mice: C. Albanese, et al.; Semin. Cell. Dev. Biol. 13, 129 (2002)
- Potent and selective partial ecdysone agonist activity of chromafenozide in Sf9 cells: T. Toya, et al.; BBRC 292, 1087 (2002)
- Development of a ponasterone A-inducible gene expression system for application in cultured skeletal muscle cells: Y.Y. Xiao, et al.; Int. J. Biochem. Cell. Biol. 35, 79 (2003)
- Development of an in vitro Reporter Gene Assay for Screening the Ecdysone Receptor Agonists in Mysid Crustacean: M. Hirano, et al.; Terrapub 141 (2010)
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