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AdipoGen Life Sciences
Asiaticoside
80
CHF
CHF 80.00
In stock
AG-CN2-0080-M01010 mgCHF 80.00
AG-CN2-0080-M05050 mgCHF 320.00
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Product Details | |
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Synonyms | Blastostimulina; Centelase; Emdecassol; Madecassol; Marticassol; FK1080; BRN 0078195; NSC 166062 |
Product Type | Chemical |
Properties | |
Formula |
C48H78O19 |
MW | 959.1 |
CAS | 16830-15-2 |
RTECS | YU9625000 |
Source/Host Chemicals | Isolated from Centella asiatica. |
Purity Chemicals | ≥95% (NMR) |
Appearance | White solid. |
Solubility | Soluble in ethanol, methanol or pyridine. Insoluble in water. |
Identity | Determined by 1H-NMR and 13C-NMR. |
InChi Key | WYQVAPGDARQUBT-NXDSUYQXBS |
Smiles | [H][C@]12CC=C3C4[C@@H](C)[C@H](C)CC[C@@]4(CC[C@@]3(C)[C@]1(C)CCC1[C@](C)(CO)[C@@H](O)[C@H](O)C[C@]21C)C(=O)O[C@@H]1O[C@H](CO[C@@H]2O[C@H](CO)[C@@H](OC3O[C@H](C)[C@H](O)[C@@H](O)[C@@H]3O)[C@H](O)[C@H]2O)[C@@H](O)[C@H](O)[C@H]1O |
Shipping and Handling | |
Shipping | AMBIENT |
Short Term Storage | +4°C |
Long Term Storage | +4°C |
Handling Advice | Keep cool and dry. |
Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
Documents | |
MSDS |
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Product Specification Sheet | |
Datasheet |
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Description
- Antibacterial.
- Human collagen I synthesis inducer. Anti-wrinkle activity.
- Shows wound healing activity. Enhances normal human skin cell migration, attachment and growth.
- Suppresses collagen expression and TGF-β/Smad signaling by inducing Smad7 and inhibiting TGF-βRI and TGF-βRII.
- Anti-inflammatory and antioxidant agent with anti-gastric ulcer activity.
- Mitogen-activated protein kinases (MAPKs), nuclear factor-κB (NF-κB), cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOSII) expression, production of serum tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) inhibitor.
- Anticancer agent. Shown to induce apoptosis and autophagy in cancer cells. Enhances antitumor activity of vincristine in cancer cells. Might be useful in cancer chemotherapy.
- Anxiolytic.
- Antidepressant-like activity.
- Hepatoprotective effects.
- CYP2C19 and CYP3A4 inhibitor.
- Neuroprotective.
- Antileishmanial activity.
- cPLA2 and sPLA2 inhibitor.
Product References
- In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica: A. Shukla, et al.; J. Ethnopharmacol. 65, 1 (1999)
- In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins: J.H. Sampson, et al.; Phytomedicine 8, 230 (2001)
- The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats: C.L. Cheng, et al.; Life Sci. 74, 2237 (2004)
- Inhibitory effects of Centella asiatica water extract and asiaticoside on inducible nitric oxide synthase during gastric ulcer healing in rats: J.S. Guo, et al.; Planta Med. 70, 1150 (2004)
- Improving lip wrinkles: lipstick-related image analysis: J.S. Ryu, et al.; Skin Res. Technol. 11, 157 (2005)
- Asiaticoside induces human collagen I synthesis through TGFbeta receptor I kinase (TbetaRI kinase)-independent Smad signaling: J. Lee, et al.; Planta Med. 72, 324 (2006)
- Anxiolytic-like effect of asiaticoside in mice: S.W. Chen, et al.; Pharmacol. Biochem. Behav. 85, 339 (2006)
- Effects of asiaticoside on the expression of Smad protein by normal skin fibroblasts and hypertrophic scar fibroblasts: S.H. Qi, et al.; Clin. Exp. Dermatol. 33, 171 (2008)
- Antidepressant-like effect of asiaticoside in mice: X. Liang, et al.; Pharmacol. Biochem. Behav. 89, 444 (2008)
- Protective effects of Asiaticoside on acute liver injury induced by lipopolysaccharide/D-galactosamine in mice: L. Zhang, et al.; Phytomedicine 17, 811 (2010)
- Asiaticoside suppresses collagen expression and TGF-β/Smad signaling through inducing Smad7 and inhibiting TGF-βRI and TGF-βRII in keloid fibroblasts: B. Tang, et al.; Arch. Dermatol. Res. 303, 563 (2011)
- In vitro inhibitory effects of asiaticoside and madecassoside on human cytochrome P450: T. Winitthana, et al.; Toxicol. In Vitro 25, 890 (2011)
- Asiaticoside: attenuation of neurotoxicity induced by MPTP in a rat model of Parkinsonism via maintaining redox balance and up-regulating the ratio of Bcl-2/Bax: C.L. Xu, et al.; Pharmacol. Biochem. Behav. 100, 413 (2012)
- Asiaticoside induces tumour-necrosis-factor-α-mediated nitric oxide production to cure experimental visceral leishmaniasis caused by antimony-susceptible and -resistant Leishmania donovani strains: S.K. Bhaumik, et al.; J. Antimicrob. Chemother. 67, 910 (2012)
- Inhibition of cPLA2 and sPLA2 activities in primary cultures of rat cortical neurons by Centella asiatica water extract: P.P. Defillipo, et al.; Nat. Prod. Commun. 7, 841 (2012)
- Asiaticoside enhances normal human skin cell migration, attachment and growth in vitro wound healing model: J.H. Lee, et al.; Phytomedicine 19, 1223 (2012)
- Antipyretic and Anti-inflammatory Effects of Asiaticoside in Lipopolysaccharide-treated Rat through Up-regulation of Heme Oxygenase-1: J. Wan, et al.; Phytother. Res. 27, 1136 (2013)
- Neuroprotective effects of Asiaticoside: F.Y. Qi, et al.; Neural. Regen. Res. 9, 1275 (2014)
- Asiaticoside attenuates the effects of spinal cord injury through antioxidant and anti‑inflammatory effects, and inhibition of the p38‑MAPK mechanism: Y. Luo, et al.; Mol. Med. Rep. 12, 8294 (2015)
- Burn wound healing properties of asiaticoside and madecassoside: Q. Hou, et al.; Exp. Ther. Med. 12, 1269 (2016)
- Effect of asiaticoside on endothelial cells in hypoxia‑induced pulmonary hypertension: X. Wang, et al.; Mol. Med. Rep. 17, 2893 (2018)
- Anti-inflammatory effect of asiaticoside on human umbilical vein endothelial cells induced by ox-LDL: L. Jing, et al.; Cytotechnology 70, 855 (2018)
- Antitumor Activity of Asiaticoside Against Multiple Myeloma Drug-Resistant Cancer Cells Is Mediated by Autophagy Induction, Activation of Effector Caspases, and Inhibition of Cell Migration, Invasion, and STAT-3 Signaling Pathway: L. Yingchun, et al.; Med. Sci. Monit. 25, 1355 (2019)