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AdipoGen Life Sciences
Pseudolaric acid B
30
CHF
CHF 30.00
In stock
AG-CN2-0083-C100100 µgCHF 30.00
AG-CN2-0083-M0011 mgCHF 90.00
| Product Details | |
|---|---|
| Synonyms | Pseudolarix acid B; PLAB; PAB |
| Product Type | Chemical |
| Properties | |
| Formula |
C23H28O8 |
| MW | 432.5 |
| CAS | 82508-31-4 |
| RTECS | KJ4620000 |
| Source/Host Chemicals | Isolated from Pseudolarix kaempferi. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO, ethanol, methanol or chloroform. |
| InChi Key | VDGOFNMYZYBUDT-YDRCMHEVSA-N |
| Smiles | [H][C@@]12CC[C@]3(CC=C(CC[C@]13OC(C)=O)C(=O)OC)C(=O)O[C@]2(C)\C=C\C=C(/C)C(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antifungal and antifertility compound [1, 3].
- Antitumor compound [2, 7-9, 13].
- PPARα signaling agonist [4].
- Angiogenesis inhibitor [5, 6, 11].
- Apoptosis and autophagy inducer [7, 9, 15, 17].
- Microtubule-destabilizing agent [8, 11].
- Anti-inflammatory. Inhibits NF-κB and p38 signaling [12, 14].
- Immunosuppressive [16].
Product References
- Pseudolaric Acids from Pseudolarix kaempferi: B.N. Zhou, et al.; Planta Med. 47, 35 (1983)
- The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives: D.J. Pan, et al.; Planta Med. 56, 383 (1990)
- Antifungal evaluation of pseudolaric acid B, a major constituent of Pseudolarix kaempferi: E. Li, et al.; J. Nat. Prod. 58, 57 (1995)
- Pseudolaric acid analogs as a new class of peroxisome proliferator-activated receptor agonists: M.S. Jardat, et al.; Planta Med. 68, 667 (2002)
- Pseudolarix acid B inhibits angiogenesis by antagonizing the vascular endothelial growth factor-mediated anti-apoptotic effect: W.F. Tan, et al.; Eur. J. Pharmacol. 499, 219 (2004)
- Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor 1alpha by promoting proteasome-mediated degradation: M.H. Li, et al.; Clin. Cancer Res. 10, 8266 (2004)
- Pseudolaric acid B induces apoptosis through p53 and Bax/Bcl-2 pathways in human melanoma A375-S2 cells: X.F. Gong, et al.; Arch. Pharm. Res. 28, 68 (2005)
- Pseudolaric acid B, a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo: V.K. Wong, et al.; Clin. Cancer Res. 11, 6002 (2005)
- Effect of pseudolaric acid B on gastric cancer cells: inhibition of proliferation and induction of apoptosis: K.S. Li, et al.; World J. Gastroenterol. 11, 7555 (2005)
- Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin: Y.G. Tong, et al.; Mol. Pharmacol. 69, 1226 (2006)
- Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death: X. Gong, et al.; Exp. Mol. Med. 38, 428 (2006)
- Pseudolaric acid B suppresses T lymphocyte activation through inhibition of NF-kappaB signaling pathway and p38 phosphorylation: T. Li, et al.; J. Cell Biochem. 108, 87 (2009)
- Selective inhibition of human leukemia cell growth and induction of cell cycle arrest and apoptosis by pseudolaric acid B: G. Ma, et al.; J. Cancer Res. Clin. Oncol. 136, 1333 (2010)
- Pseudolaric acid B inhibits inducible cyclooxygenase-2 expression via downregulation of the NF-κB pathway in HT-29 cells: L. Hou, et al.; J. Cancer Res. Clin. Oncol. 138, 885 (2012)
- Pseudolaric acid B induces apoptosis via proteasome-mediated Bcl-2 degradation in hormone-refractory prostate cancer DU145 cells: D. Zhao, et al.; Toxicol. In Vitro 26, 595 (2012)
- The Immunosuppressive Activity of Pseudolaric Acid B on T lymphocytes in vitro: N. Wei, et al: Phytother. Res. 27, 980 (2013)
- Pseudolaric Acid B Induces Caspase-Dependent Apoptosis and Autophagic Cell Death in Prostate Cancer Cells: J. Tong, et al.; Phytother. Res. 27, 885 (2013)
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