AdipoGen Life Sciences

Amidepsine A

CHF 280.00
In stock
AG-CN2-0109-M0011 mgCHF 280.00
AG-CN2-0109-MM252.5 mgCHF 580.00
More Information
Product Details
Product Type Chemical
Properties
Formula

C29H29NO11

MW 567.6
CAS 169181-28-6
Source/Host Chemicals Isolated from Humcola sp. FO-2942.
Purity Chemicals ≥95% (HPLC)
Appearance Pale white powder.
Solubility Soluble in methanol, benzene or ethyl acetate. Insoluble in water or hexane.
InChi Key XQGKRCPZJSNFEL-UHFFFAOYSA-N
Smiles COC1=CC(OC)=C(C(=O)OC2=CC(C)=C(C(=O)OC3=CC(C)=C(C(=O)NC(C)C(O)=O)C(O)=C3)C(O)=C2)C(C)=C1
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Diacylglycerol acyltransferase (DGAT) inhibitor [1-4].
  • Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Product References
  1. Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 48, 937 (1995)
  2. Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot. 48, 942 (1995)
  3. Amidepsine E, an inhibitor of diacylglycerol acyltransferase produced by Humicola sp. FO-5969: H. Tomoda, et al.; J. Antibiot. 49, 929 (1996)
  4. Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms: H. Tomoda & S. Omura; Pharmacol. Ther. 115, 375 (2007)
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