AdipoGen Life Sciences

Amidepsine A

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AG-CN2-0109-M0011 mgCHF 250.00

AG-CN2-0109-MM252.5 mgCHF 500.00

Specifications / Handling

More Information
Product Details
Product Type	Chemical
Properties
Formula	C₂₉H₂₉NO₁₁
MW	567.6
CAS	169181-28-6
Source/Host Chemicals	Isolated from Humcola sp. FO-2942.
Purity Chemicals	≥95% (HPLC)
Appearance	Pale white powder.
Solubility	Soluble in methanol, benzene or ethyl acetate. Insoluble in water or hexane.
InChi Key	XQGKRCPZJSNFEL-UHFFFAOYSA-N
Smiles	COC1=CC(OC)=C(C(=O)OC2=CC(C)=C(C(=O)OC3=CC(C)=C(C(=O)NC(C)C(O)=O)C(O)=C3)C(O)=C2)C(C)=C1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product Description

Diacylglycerol acyltransferase (DGAT) inhibitor [1-4].
Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.

Product-specific References

Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 48, 937 (1995)
Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot. 48, 942 (1995)
Amidepsine E, an inhibitor of diacylglycerol acyltransferase produced by Humicola sp. FO-5969: H. Tomoda, et al.; J. Antibiot. 49, 929 (1996)
Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms: H. Tomoda & S. Omura; Pharmacol. Ther. 115, 375 (2007)

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