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AdipoGen Life Sciences
Amidepsine D
280
CHF
CHF 280.00
In stock
AG-CN2-0110-M0011 mgCHF 280.00
AG-CN2-0110-MM252.5 mgCHF 580.00
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula |
C26H24O10 |
| MW | 496.5 |
| CAS | 79786-34-8 |
| Source/Host Chemicals | Isolated from Humcola sp. FO-2942. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to light pink powder. |
| Solubility | Soluble in methanol, benzene or ethyl acetate. Insoluble in water or hexane. |
| InChi Key | KODVVMZOLYYCMV-UHFFFAOYSA-N |
| Smiles | COC1=CC(OC)=C(C(=O)OC2=CC(C)=C(C(=O)OC3=CC(C)=C(C(O)=O)C(O)=C3)C(O)=C2)C(C)=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Diacylglycerol acyltransferase (DGAT) inhibitor [1-4].
- Excessive accumulation of triacetylglycerol produced by DGAT may cause fatty liver, obesity and hypertriglyceridemia, which may lead to atherosclerosis, diabetes and metabolic disorders.
Product References
- Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. I. Production, isolation and biological properties: H. Tomoda, et al.; J. Antibiot. 48, 937 (1995)
- Amidepsines, inhibitors of diacylglycerol acyltransferase produced by Humicola sp. FO-2942. II. Structure elucidation of amidepsines A, B and C: H. Tomoda, et al.; J. Antibiot. 48, 942 (1995)
- Amidepsine E, an inhibitor of diacylglycerol acyltransferase produced by Humicola sp. FO-5969: H. Tomoda, et al.; J. Antibiot. 49, 929 (1996)
- Potential therapeutics for obesity and atherosclerosis: inhibitors of neutral lipid metabolism from microorganisms: H. Tomoda & S. Omura; Pharmacol. Ther. 115, 375 (2007)
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