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AdipoGen Life Sciences
GE2270 D2
110
CHF
CHF 110.00
In stock
AG-CN2-0304-M0011 mgCHF 110.00
AG-CN2-0304-M0055 mgCHF 380.00
AG-CN2-0304-M02525 mgCHF 1'140.00
| Product Details | |
|---|---|
| Synonyms | Antibiotic GE2270D2 |
| Product Type | Chemical |
| Properties | |
| Formula |
C55H53N15O10S6 |
| MW | 1276.5 |
| CAS | 138948-60-4 |
| Source/Host Chemicals | Isolated from Planobispora rosea. |
| Purity Chemicals | ≥80% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO or other organic solvents. |
| Identity | Determined by 1H-NMR and MS. |
| Declaration | Manufactured by Naicons Srl. |
| Other Product Data |
Purity Note:The purity is referred exclusively to the main congener(s), the sample also contains minor related congeners. See: Components of the GE2270 complex produced by Planobispora rosea ATCC 53773: E. Selva, et al.; J. Antibiot. 48, 1039 (1995) |
| InChi Key | OKGFXSMHEYOSSF-UHFFFAOYSA-N |
| Smiles | OCC1=C(C(NCC(NC(C(C2=CC=CC=C2)O)C3=NC(C4=NC(C5=C(C=CC(C6=NC(C7=NC(C(N8C(CCC8)C(N)=O)=O)CO7)=CS6)=N5)C9=NC(C(NC(CC(NC)=O)C%10=NC(C(NC%11C(C)C)=O)=C(C)S%10)=O)=CS9)=CS4)=CS3)=O)=O)N=C%11S1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from light when in solution. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Thiopeptide antibiotic. Congener of GE2270A (AG-CN2-0303). Used as a starting scaffold bearing a free hydroxy group, for the production of new interesting semi-synthetic antibiotics.
- Antibacterial agent by inhibiting bacterial protein synthesis. Active against numerous Gram-positive pathogens.
- Inhibitor of elongation factor Tu (EF-Tu).
- Inhibits protein synthesis by blocking the GDP to GTP conformational change and by directly competing with aminoacyl-tRNA for the same binding site on EF-Tu.
Product References
- Antibiotic GE2270 A: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization: E. Selva, et al.; J. Antibiot. 44, 693 (1991)
- Components of the GE2270 complex produced by Planobispora rosea ATCC 53773: E. Selva, et al.; J. Antibiot. 48, 1039 (1995)
- Contribution of mass spectrometry to the structural confirmation of components of the antibiotic GE2270 complex: L. Colombo, et al.; Rap. Commun. Mass. Spec. 9, 717 (1995)
- Antimicrobial activities of chemically modified thiazolyl peptide antibiotic MDL 62,879 (GE2270A): S. Lociuro, et al.; J. Antibiot. 50, 344 (1997)
- Capturing linear intermediates and C-terminal variants during maturation of the thiopeptide GE2270: A. Tocchetti, et al.; Chem. Biol. 20, 1067 (2013)
- Elfamycins: inhibitors of elongation factor-Tu: S.M. Prezioso, et al.; Mol. Microbiol. 106, 22 (2017) (Review)
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