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AdipoGen Life Sciences
GE2270A
110
CHF
CHF 110.00
In stock
AG-CN2-0303-M0011 mgCHF 110.00
AG-CN2-0303-M0055 mgCHF 380.00
AG-CN2-0303-M02525 mgCHF 1'140.00
| Product Details | |
|---|---|
| Synonyms | Antibiotic GE 2270A; MDL 62879 |
| Product Type | Chemical |
| Properties | |
| Formula |
C56H55N15O10S6 |
| MW | 1290.5 |
| CAS | 134861-34-0 |
| Source/Host Chemicals | Isolated from Planobispora rosea. |
| Purity Chemicals | ≥95% (HPLC) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO or other organic solvents. |
| Identity | Determined by 1H-NMR and MS. |
| Declaration | Manufactured by Naicons Srl. |
| Other Product Data |
Purity Note: The purity is referred exclusively to the main congener(s), the sample also contains minor related congeners. See: Components of the GE2270 complex produced by Planobispora rosea ATCC 53773: E. Selva, et al.; J. Antibiot. 48, 1039 (1995) |
| InChi Key | JMDULECOHIXMNX-CORBLQQCSA-N |
| Smiles | O=C1C2=CSC(C3=CC=C(C4=NC(C5=N[C@H](C(N6[C@@H](CCC6)C(N)=O)=O)CO5)=CS4)N=C3C7=CSC(C8=CSC(C(NC(CNC(C9=C(COC)SC([C@H](C(C)C)NC(C%10=C(C)SC([C@@](CC(NC)=O)([H])N1)=N%10)=O)=N9)=O)=O)[C@H](C%11=CC=CC=C%11)O)=N8)=N7)=N2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. Protect from light when in solution. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
-
Thiopeptide antibiotic.
-
Antibacterial agent by inhibiting bacterial protein synthesis.
-
Active against numerous Gram-positive pathogens, including methicillin-resistant strains of Staphylococcus aureus and vancomycin-resistant Enterococcus spp.
-
Inhibitor of domain II of elongation factor Tu (EF-Tu).
-
Inhibits protein synthesis by blocking the GDP to GTP conformational change and by directly competing with aminoacyl-tRNA for the same binding site on EF-Tu.
Product References
- Antibiotic GE2270 A: a novel inhibitor of bacterial protein synthesis. I. Isolation and characterization: E. Selva, et al.; J. Antibiot. 44, 693 (1991)
- Antibiotic GE2270 A: a novel inhibitor of bacterial protein synthesis. II. Structure elucidation: J. Kettenring, et al.; J. Antibiot. 44, 702 (1991)
- Probing the reactivity of the GTP- and GDP-bound conformations of elongation factor Tu in complex with the antibiotic GE2270 A: P.H. Anborgh & A. Parmeggiani; J. Biol. Chem. 268, 24622 (1993)
- In vitro Antimicrobial Activity of the Thiazolyl Peptide Antibiotic MDL 62,879 (GE2270 A): M.T. Kenny, et al.; Chemotherapy 43, 254 (1997)
- Structure of an EF-Tu Complex with a Thiazolyl Peptide Antibiotic Determined at 2.35 Å Resolution: Atomic Basis for GE2270A Inhibition of EF-Tu: S.E. Heffron & F. Jurnak; Biochemistry 39, 37 (2000)
- Structural basis of the action of pulvomycin and GE2270 A on elongation factor Tu: A. Parmeggiani, et al.; Biochemistry 45, 6846 (2006)
- Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins: C.T. Walsh, et al.; J. Biol. Chem. 285, 27525 (2010)
- Elfamycins: inhibitors of elongation factor-Tu: S.M. Prezioso, et al.; Mol. Microbiol. 106, 22 (2017) (Review)
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