Papaverine . hydrochloride

CHF 30.00
In stock
AG-CN2-0414-G0011 gCHF 30.00
AG-CN2-0414-G0055 gCHF 90.00
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Product Details
Synonyms 6,7-Dimethoxy-1-veratrylisoquinoline; NSC 35443; NCI-C56359
Product Type Chemical

C20H21NO4 . HCl

MW 339.4 . 36.5
CAS 61-25-6
RTECS NW8575000
Source/Host Chemicals Synthetic. Originally isolated from Papaver somniferum.
Purity Chemicals ≥95% (NMR)
Appearance White to off-white crystalline powder.
Solubility Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water.
Identity Identity determined by 1H-NMR.
Smiles COC1=CC=C(CC2=NC=CC3=CC(OC)=C(OC)C=C23)C=C1OC
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Protect from light.
Protect from moisture.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Smooth muscle relaxant and vasodilator [4].
  • Phosphodiesterase PDE10A inhibitor [3,5,6].
  • Antiviral [1,2].
  • Antipsychotic [3].
  • Potential inducer of browning in WAT.
Product References
  1. Effect of papaverine treatment on replication of measles virus in human neural and nonneural cells: Y. Yoshikawa & K. Yamanouchi; J. Virol. 50, 489 (1984)
  2. Papaverine hydrochloride: effects on HIV replication and T-lymphocyte cell function: M. Nokta, et al.; Immunopharmacol. 26, 181 (1993)
  3. Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis: J.A. Siuciak, et al.; Neuropharmacol. 51, 386 (2006)
  4. The effect of papaverine on ion channels in rat basilar smooth muscle cells: D.H. Han, et al.; Neurol. Res. 29, 544 (2007)
  5. The PDE10A inhibitor, papaverine, differentially activates ERK in male and female rat striatal slices: Y.T. Hsu, et al.; Neuropharmacol. 61, 1275 (2011)
  6. PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a huntington's disease mouse model: A. Giralt, et al.; Hippocampus 23, 684 (2013)
  7. A novel thermoregulatory role for PDE10A in mouse and human adipocytes: M.K. Hankir, et al.; EMBO Mol. Med. 8, 796 (2016)
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