Papaverine . hydrochloride
AG-CN2-0414-G0011 gCHF 30.00
AG-CN2-0414-G0055 gCHF 90.00
|Synonyms||6,7-Dimethoxy-1-veratrylisoquinoline; NSC 35443; NCI-C56359|
C20H21NO4 . HCl
|MW||339.4 . 36.5|
|Source/Host Chemicals||Synthetic. Originally isolated from Papaver somniferum.|
|Purity Chemicals||≥95% (NMR)|
|Appearance||White to off-white crystalline powder.|
|Solubility||Soluble in DMSO, ethanol or dimethylformamide. Sparingly soluble in water.|
|Identity||Identity determined by 1H-NMR.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
Protect from light.
Protect from moisture.
|Use/Stability||Stable for at least 2 years after receipt when stored at -20°C.|
|Product Specification Sheet|
- Smooth muscle relaxant and vasodilator .
- Phosphodiesterase PDE10A inhibitor [3,5,6].
- Antiviral [1,2].
- Antipsychotic .
- Potential inducer of browning in WAT.
- Effect of papaverine treatment on replication of measles virus in human neural and nonneural cells: Y. Yoshikawa & K. Yamanouchi; J. Virol. 50, 489 (1984)
- Papaverine hydrochloride: effects on HIV replication and T-lymphocyte cell function: M. Nokta, et al.; Immunopharmacol. 26, 181 (1993)
- Inhibition of the striatum-enriched phosphodiesterase PDE10A: a novel approach to the treatment of psychosis: J.A. Siuciak, et al.; Neuropharmacol. 51, 386 (2006)
- The effect of papaverine on ion channels in rat basilar smooth muscle cells: D.H. Han, et al.; Neurol. Res. 29, 544 (2007)
- The PDE10A inhibitor, papaverine, differentially activates ERK in male and female rat striatal slices: Y.T. Hsu, et al.; Neuropharmacol. 61, 1275 (2011)
- PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a huntington's disease mouse model: A. Giralt, et al.; Hippocampus 23, 684 (2013)
- A novel thermoregulatory role for PDE10A in mouse and human adipocytes: M.K. Hankir, et al.; EMBO Mol. Med. 8, 796 (2016)