Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
IBMX
120
CHF
CHF 120.00
In stock
AG-CR1-3512-M500500 mgCHF 120.00
AG-CR1-3512-G0011 gCHF 200.00
| Product Details | |
|---|---|
| Synonyms | 3-Isobutyl 1-methylxanthine; NSC 165960; EINECS 249-259-3 |
| Product Type | Chemical |
| Properties | |
| Formula |
C10H14N4O2 |
| MW | 222.3 |
| CAS | 28822-58-4 |
| RTECS | ZD8500000 |
| Purity Chemicals | ≥99% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (20mg/ml), ethanol (10mg/ml) or methanol (10mg/ml). Insoluble in water. |
| Identity | Determined by 1H-NMR. |
| InChi Key | APIXJSLKIYYUKG-UHFFFAOYSA-N |
| Smiles | CC(C)CN1C2=C(NC=N2)C(=O)N(C)C1=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Stock solutions are stable for at least 3 months when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Cell permeable, competitive, non-specific cAMP and cGMP phosphodiesterase inhibitor [1, 5, 6, 11].
- Increases cAMP levels that activate PKA, leading to decreased proliferation, increased differentiation and induction of apoptosis [9].
- Enhances differentiation of 3T3-L1 cells [3].
- Non-selective adenosine receptor antagonist [4].
- Inhibits Ca2+ ion channels [7, 8].
- Activates TNF-α [10].
- Adipogenic [10].
- Activates leukotriene synthesis [12].
- Reduces inflammation and innate immunity [12].
Product References
- Effects of xanthine derivatives on lipolysis and on adenosine 3',5'- monophosphate phosphodiesterase activity: J.A. Beavo, et al.; Mol. Pharmacol. 6, 597 (1970)
- Inhibition of growth of primary and metastatic Lewis lung carcinoma cells by the phosphodiesterase inhibitor isobutylmethylxanthine: P. Janik, et al.; Cancer Res. 40, 1950 (1980)
- A role for soluble cAMP phosphodiesterases in differentiation of 3T3-L1adipocytes: M.L. Elks & V.C. Manganiello; J. Cell Physiol. 124, 191 (1985)
- Adenosine receptors: development of selective agonists and antagonists: J.W. Daly, et al.; Prog. Clin. Biol. Res. 230, 41 (1987)
- Primary sequence of cyclic nucleotide phosphodiesterase isozymes and the design of selective inhibitors: J.A. Beavo & D.H. Reifsnyder; TIPS 11, 150 (1990)
- Isobutylmethylxanthine and other classical cyclic nucleotide phosphodiesterase inhibitors affect cAMP-dependent protein kinase activity: C. Tomes, et al.; Cell Signal. 5, 615 (1993)
- IBMX induces calcium release from intracellular stores in rat sensory neurones: Y. Usachev & A. Verkhratsky; Cell Calcium 17, 197 (1995)
- Inhibition of recombinant human cardiac L-type Ca2+ channel α1C subunits by 3-isobutyl-1-methylxanthine: I.M. Fearon, et al.; Eur. J. Pharmacol. 342, 353 (1998)
- Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas: T.C. Chen, et al.; Lab. Invest. 78, 165 (1998)
- The phosphodiesterase inhibitor IBMX suppresses TNF-alpha expression in human adipocyte precursor cells: a possible explanation for its adipogenic effect: F. Hube, et al.; Horm. Metab. Res. 31, 359 (1999)
- Cyclic nucleotide phosphodiesterases: D.M. Essayan; J. Allergy Clin. Immunol. 108, 671 (2001)
- Leukotrienes: underappreciated mediators of innate immune responses: M. Peters-Golden, et al.; J. Immunol. 174, 589 (2005)
Related Products
