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AdipoGen Life Sciences
Cyclosporin D
110
CHF
CHF 110.00
In stock
AG-CN2-0445-M0011 mgCHF 110.00
AG-CN2-0445-M0055 mgCHF 250.00
| Product Details | |
|---|---|
| Synonyms | Val2-Cyclosporine; CsD |
| Product Type | Chemical |
| Properties | |
| Formula |
C63H113N11O12 |
| MW | 1216.7 |
| Merck Index | 14: 2752 |
| CAS | 63775-96-2 |
| Source/Host Chemicals | Isolated from Fusarium solani. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in 100% ethanol, acetone or ethyl acetate; insoluble in water. |
| InChi Key | ZNVBEWJRWHNZMK-AHWIEGLVSA-N |
| Smiles | [H][C@@]1([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)C(NC1=O)C(C)C)C(C)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent inhibitor of tumor promoting phorbol ester TPA/PMA (AG-CN2-0010) effects in vivo.
- Antifungal.
- Moderate immunosuppressant. Calcineurin inhibitor with lower activity than Cyclosporin A (AG-CN2-0079).
- Moderate inhibitor of formyl peptide-induced superoxide formation.
Product References
- Effect of column temperature and eluent flow rate on the high performance liquid chromatographic analysis of cyclosporin a and d: K.A. Mereish & C.T. Ueda; Pharm. Res. 1, 245 (1984)
- The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC 150, 545 (1988)
- Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation: K. Wentzel-Seifert, et al.; J. Immunol. 147, 1940 (1991)
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