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AdipoGen Life Sciences
Cyclosporin H
120
CHF
CHF 120.00
In stock
AG-CN2-0447-M0011 mgCHF 120.00
AG-CN2-0447-M0055 mgCHF 360.00
| Product Details | |
|---|---|
| Synonyms | D-MeVal11-Cyclosporine; CsH |
| Product Type | Chemical |
| Properties | |
| Formula |
C62H111N11O12 |
| MW | 1202.6 |
| CAS | 83602-39-5 |
| Source/Host Chemicals | Isolated from Tolypocladium inflatum. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White solid. |
| Solubility | Soluble in 100% ethanol (20mg/ml), DMSO (40mg/ml), DMF, acetone or ethyl acetate. Insoluble in water. |
| Identity | Determined by MS. |
| InChi Key | PMATZTZNYRCHOR-DAYHEYMASA-N |
| Smiles | [H][C@@]1([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)C(CC)NC1=O)C(C)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent inhibitor of tumor promoting phorbol ester TPA/PMA (AG-CN2-0010) effects in vivo.
- Antifungal.
- Potent and effective inhibitor of formyl peptide receptor (FPR) and formyl peptide-induced superoxide formation.
- Shows no immunosuppresive activity like other cyclosporins.
Product References
- The weak immunosuppressant cyclosporine D as well as the immunologically inactive cyclosporine H are potent inhibitors in vivo of phorbol ester TPA-induced biological effects in mouse skin and of Ca2+/calmodulin dependent EF-2 phosphorylation in vitro: M. Gschwendt, et al.; BBRC 150, 545 (1988)
- Differential inhibition of human neutrophil activation by cyclosporins A, D, and H. Cyclosporin H is a potent and effective inhibitor of formyl peptide-induced superoxide formation: K. Wenzel-Seifert, et al.; J. Immunol. 147, 1940 (1991)
- Cyclosporin H, Boc-MLF and Boc-FLFLF are antagonists that preferentially inhibit activity triggered through the formyl peptide receptor: A.L. Stenfeldt, et al.; Inflammation 30, 224 (2007)
- Annexin A1/Formyl Peptide Receptor Pathway Controls Uterine Receptivity to the Blastocyst: C.B. Hebeda, et al.; Cells 9, 1188 (2020)
- The f subunit of human ATP synthase is essential for normal mitochondrial morphology and permeability transition: C. Galber, et al.; Cell Rep. 35, 109111 (2021)
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