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AdipoGen Life Sciences
Myxochelin A
120
CHF
CHF 120.00
In stock
AG-CN2-0470-C100100 µgCHF 120.00
AG-CN2-0470-M0011 mgCHF 420.00
| Product Details | |
|---|---|
| Synonyms | (S)-N,N'-(6-Hydroxyhexane-1,5-diyl)bis(2,3-dihydroxybenzamide) |
| Product Type | Chemical |
| Properties | |
| Formula |
C20H24N2O7 |
| MW | 404.4 |
| CAS | 120243-02-9 |
| Source/Host Chemicals | Synthetic. Originally isolated from Pyxidicoccus fallax HKI 727. |
| Purity Chemicals | ≥99% (NMR) |
| Appearance | Solid. |
| Solubility | Soluble in DMSO, ethanol, methanol, acetone, ethylacetate or chloroform. Insoluble in water or hexane. |
| Identity | Determined by 1H-NMR. |
| InChi Key | WNBVGSNESTZACV-LBPRGKRZSA-N |
| Smiles | OC[C@H](CCCCNC(=O)C1=C(O)C(O)=CC=C1)NC(=O)C1=CC=CC(O)=C1O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Stable for at least 1 year after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent inhibitor of human 5-lipoxygenase (5-LO). This enzyme catalyzes two initial steps in the conversion of arachidonic acid into leukotrienes, well known mediators of inflammatory and allergic reactions.
- Iron-chelating compound.
- Anticancer antibiotic. Shown to inhibit tumor cell invasion in vitro.
- Antibacterial compound.
- Antioxidant with free radical scavenging activities.
Product References
- Myxochelin A, a new iron-chelating compound from Angiococcus disciformis (Myxobacterales). Production, isolation, physico-chemical and biological properties: B. Kunze, et al.; J. Antibiot. 42, 14 (1989)
- Myxochelin A, a cytotoxic antibiotic from the myxobacterium Angiococcus disciformis: J.W. Ahn, et al.; OPEM 2, 64 (2001)
- Antioxidative and free radical scavenging activities of Myxochelin A isolated from Angiococcus sp.(Myxobacteria): H.-H. Lee, et al.; Food Sci. Biotech. 11, 184 (2002)
- Absolute configuration and antitumor activity of myxochelin A produced by Nonomuraea pusilla TP-A0861: S. Miyanaga, et al.; J. Antibiot. 59, 698 (2006)
- Synthesis and evaluation of myxochelin analogues as antimetastatic agents: S. Miyanaga, et al.; Bioorg. Med. Chem. 17, 2724 (2009)
- Myxochelins target human 5-lipoxygenase: S. Schieferdecker, et al.; J. Nat. Prod. 78, 335 (2015)
- Harnessing enzymatic promiscuity in Myxochelin biosynthesis for the production of 5-Lipoxygenase inhibitors: J. Korp, et al.; Chembiochem. 16, 2445 (2015)
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