AdipoGen Life Sciences

Aranorosinol B

CHF 230.00
In stock
AG-CN2-0494-M0011 mgCHF 230.00
More Information
Product Details
Product Type Chemical
Properties
Formula

C26H39NO7

MW 477.6
CAS 145147-05-3
Source/Host Chemicals Isolated from Phoma sp.
Purity Chemicals ≥94% (HPLC)
Appearance White solid.
Solubility Soluble in DMSO, ethanol or methanol.
Identity Determined by 1H-NMR and MS.
InChi Key YFJWRMZGLWVCSQ-ZXTVQVQKSA-N
Smiles CCCCCC[C@@H](C)/C=C(C)/C=C/C(N[C@@H]1C(O)O[C@]2([C@H](O3)[C@H]3C(CC(C)=O)(O)[C@H]4[C@@H]2O4)C1)=O
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice Keep cool and dry.
Protect from light.
Use/Stability Stable for at least 1 year after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
Description
  • Antibiotic. Moderate antibacterial and antifungal agent.
  • Inhibits the autophosphorylation of histidine kinase WalK/YycG. The WalK/WalR (aka YycG/YycF) two-component system is indispensable in the signal transduction pathway for the cell-wall metabolism/synthesis.
Product References
  1. Aranorosinol A and Aranorosinol B, two new metabolites from Pseudoarachniotus roseus: production, isolation, structure elucidation and biological properties: K. Roy, et al.; J. Antibiot. 45, 1592 (1992)
  2. Isolation and characterization of inhibitors of the essential histidine kinase, YycG in Bacillus subtilis and Staphylococcus aureus: T. Watanabe, et al.; J. Antibiot. 56, 1045 (2003)
  3. Cytotoxic acyl amides from the soil fungus Gymnascella dankaliensis: L. Hammerschmidt, et al.; Bioorg. Med. Chem. 23, 712 (2015)
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