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AdipoGen Life Sciences
Antipain . dihydrochloride
45
CHF
CHF 45.00
In stock
AG-CP3-7002-M0055 mgCHF 45.00
AG-CP3-7002-M02525 mgCHF 170.00
| Product Details | |
|---|---|
| Synonyms | [(S)-1-Carboxy-2-phenylethyl]-carbamoyl-Arg-Val-arginal . 2HCl |
| Product Type | Chemical |
| Properties | |
| Formula |
C27H44N10O6 . 2HCl |
| MW | 604.7 . 72.9 |
| CAS | 37682-72-7 |
| RTECS | YV9350800 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in water, ethanol, methanol, DMSO or acetonitrile. |
| Biological Activity |
Inhibitory Activity: ≥30 U/mg (Trypsin, L-BAPA) |
| InChi Key | YAHXZYICKJUJEO-BXLPLHKWSA-N |
| Smiles | [Cl-].[Cl-].[H]C(=O)C(CCCNC(N)=[NH2+])NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=[NH2+])NC(=O)NC(CC1=CC=CC=C1)C(O)=O)C(C)C |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 3 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent reversible inhibitor of serine/cysteine proteases and some trypsin-like proteases. Inhibits papain, trypsin and trypsin-like serine proteases as well as cathepsin A, B and D.
- Similar activity spectrum comparable to leupeptin (AG-CP3-7000).
- Acts by forming a hemiacetal adduct between its aldehyde group and the active serine of the proteinase.
- Inhibits transformation of NIH3T3 cells after transfection with an activated H-ras oncogene.
- Used to evaluate the role of proteases in the process of malignant cell transformations.
- Shows antibacterial and antiparasitic activity.
Product References
- Antipain, a new protease inhibitor isolated from actinomycetes: H. Suda, et al.; J. Antibiot. 25, 263 (1972)
- Structures and activities of protease inhibitors of microbial origin: H. Umezawa; Methods Enzymol. 45, 678 (1976)
- Inhibition of proteolytic activity of calcium activated neutral protease by leupeptin and antipain: T. Toyo-Oka, et al.; BBRC 82, 484 (1978)
- Effects of antipain (a protease inhibitor) on respiration, viability, and excision of pyrimidine dimers in UV-irradiated Escherichia coli cells: P.A. Swenson & R.L. Schenley; J. Bacteriol. 135, 1167 (1978)
- Effect of Ca2+ on the inhibition of calcium-activated neutral protease by leupeptin, antipain and epoxysuccinate derivatives: K. Suzuki, et al.; FEBS Lett. 136, 119 (1981)
- Inhibition of Leishmania amastigote growth by antipain and leupeptin: G.H. Coombs & J. Baxter; Ann. Trop. Med. Parasitol. 78, 21 (1984)
- Antipain or leupeptin in combination with aspirin or indomethacin synergistically inhibit human platelet activation by thrombin and trypsin: M. Ruggiero & E.G. Lapetina; Adv. Prostaglandin Thromboxane Leukot. Res. 17A, 563 (1987)
- Inhibition of H-ras oncogene transformation of NIH3T3 cells by protease inhibitors: S.J. Garte, et al.; Cancer Res. 47, 3159 (1987)
- Reversible conversion of tyrosine hydroxylase to an inactive form by antipain: S. Okuno & H. Fujisawa; BBRC 146, 1375 (1987)
- Antipain-induced suppression of oncogene expression in H-ras-transformed NIH3T3 cells: L.R. Cox, et al.; Cancer Res. 51, 4810 (1991)
- Effects of the protease inhibitor antipain on cell malignant transformation: M. Vaccari, et al.; Anticancer Res. 19, 589 (1999)
- Lysosomes, growth factor activity, and carcinogenic implications: M. Melzer; Crit. Rev. Eukaryot. Gene. Expr. 22, 345 (2012)
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