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AdipoGen Life Sciences
1400W . dihydrochloride
60
CHF
CHF 60.00
In stock
AG-CR1-0018-M0055 mgCHF 60.00
AG-CR1-0018-M02525 mgCHF 210.00
AG-CR1-0018-M100100 mgCHF 650.00
| Product Details | |
|---|---|
| Synonyms | N-(3-(Aminomethyl)benzyl)acetamidine . 2HCl |
| Product Type | Chemical |
| Properties | |
| Formula |
C10H15N3 . 2HCl |
| MW | 177.3 . 72.9 |
| CAS | 214358-33-5 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in water, methanol or DMSO. |
| InChi Key | WDJHSQZCZGPGAA-UHFFFAOYSA-N |
| Smiles | [Cl-].[Cl-].CC(=N)[NH2+]CC1=CC=CC(C[NH3+])=C1 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Hygroscopic. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd ≤ 7 nM) [1, 3, 4, 6].
- Weak and reversible inhibition of nNOS (neuronal nitric oxide synthase/NOS I) (Ki ≤ 2) and eNOS (endothelial nitric oxide synthase/NOS III) (Ki ≤ 50 μM) [1].
- Inhibits tumor growth [2].
- Increases vasoconstriction to noradrenaline [7].
- Improves contractile function [8].
- Improves stroke outcome and decreases glutamate release [9].
- Anti-inflammatory [10].
- Significant AMPK activity suppressor.
- Review [5].
Product References
- 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo: E.P. Garvey, et al.; J. Biol. Chem. 272, 4959 (1997)
- Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor: L.L. Thomsen, et al.; Cancer Res. 57, 3300 (1997)
- Actions of isoform-selective and non-selective nitric oxide synthase inhibitors on endotoxin-induced vascular leakage in rat colon: F. Laszlo & B.J.R. Whittle; Eur. J. Pharmacol. 334, 99 (1997)
- The inhibitory potency and selectivity of arginine substrate site nitric-oxide synthase inhibitors is solely determined by their affinity toward the different isoenzymes: R. Boer, et al.; Mol. Pharmacol. 58, 1026 (2000)
- Nitric oxide synthases: structure, function and inhibition: W.K. Alderton, et al.; Biochem. J. 357, 593 (2001)
- Structural basis for the specificity of the nitric-oxide synthase inhibitors W1400 and Nomega-propyl-L-Arg for the inducible and neuronal isoforms: R. Fedorov, et al.; J. Biol. Chem. 278, 45818 (2003)
- Increased vasoconstriction to noradrenaline by 1400W, inhibitor of iNOS, in rats with streptozotocin-induced diabetes: X. Cheng & C.C. Pang; Eur. J. Pharmacol. 484, 263 (2004)
- Inhibition of iNOS with 1400W improves contractile function and alters nos gene and protein expression in reperfused skeletal muscle: P. Patel, et al.; Microsurgery 24, 324 (2004)
- Inhibition of iNOS activity by 1400W decreases glutamate release and ameliorates stroke outcome after experimental ischemia: F.J. Perez-Asensio, et al.; Neurobiol. Dis. 18, 375 (2005)
- Selective iNOS inhibitor 1400W enhances anti-catabolic IL-10 and reduces destructive MMP-10 in OA cartilage. Survey of the effects of 1400W on inflammatory mediators produced by OA cartilage as detected by protein antibody array: K. Järvinen, et al.; Clin. Exp. Rheumatol. 26, 275 (2008)
- Glucose Metabolism and AMPK Signaling Regulate Dopaminergic Cell Death Induced by Gene (α-Synuclein)-Environment (Paraquat) Interactions: A. Anandhan, et al.; Mol. Neurobiol. 54, 3825 (2017)
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