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AdipoGen Life Sciences
SIN-1 chloride
35
CHF
CHF 35.00
In stock
AG-CR1-0027-M01010 mgCHF 35.00
AG-CR1-0027-M05050 mgCHF 140.00
| Product Details | |
|---|---|
| Synonyms | 3-Morpholinosydnonimine; Linsidomine |
| Product Type | Chemical |
| Properties | |
| Formula |
C6H11ClN4O2 |
| MW | 206.6 |
| CAS | 16142-27-1 |
| RTECS | WU7687800 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in 100% ethanol, water or DMSO (> 5 mg/ml). |
| Identity | Determined by 1H-NMR. |
| Other Product Data |
Use freshly prepared solutions. |
| InChi Key | ZRFWHHCXSSACAW-UHFFFAOYSA-M |
| Smiles | NC1=C[N+](N2CCOCC2)=NO1.[Cl-] |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Nitric oxide (NO) donor [1].
- Generates both superoxide anion and nitric oxide that spontaneously form peroxynitrite [1].
- Platelet aggregation inhibitor [2, 3].
- Guanylyl cyclase activator [2, 3].
- Cytotoxic [4].
- Positive ionotropic [5].
- Vasodilator [6].
Product References
- Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide: N. Hogg et al.; Biochem. J. 281|419 (1992)
- Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites: M. Nishikawa et al.; J. Phar.macol. Exp. Ther. 220, 183 (1982)
- Synergistic platelet antiaggregatory effects of the adenylate cyclase activator iloprost and the guanylate cyclase activating agent SIN-1 in vivo: M. Spiecker, et al.; Thromb. Res. 70, 405 (1993)
- SIN-1 cytotoxicity to PC12 cells is mediated by thiol-sensitive short-lived substances generated through SIN-1 decomposition in culture medium: K. Konishi, et al.; Nitric Oxide 20, 270 (2009)
- cAMP-independent activation of protein kinase A by the peroxynitrite generator SIN-1 elicits positive inotropic effects in cardiomyocytes: M.J. Kohr, et al.; J. Mol. Cell. Cardiology 48, 645 (2010)
- Response of coronary arteries to nitrates, the EDRF-donor SIN-1, and calcium antagonists: W. Schulz & G. Kober; Basic Res. Cardiol. 86, 233 (1991)
- Lipopolysaccharide (LPS)-mediated priming of toll-like receptor 4 enhances oxidant-induced prostaglandin E2 biosynthesis in primary murine macrophages: Y. Zhang & O.J. Igwe; Int. Pharmacol. 54, 226 (2017)
- Exogenous oxidants activate nuclear factor kappa B through Toll-like receptor 4 stimulation to maintain inflammatory phenotype in macrophage: Y. Zhang & O.J. Igwe; Biochem. Pharmacol. ahead of print (2017)
- Role of nitric oxide on zymosan-induced inhibition of crop emptying in chicks: M. Takahashi, et al.; Comp. Biochem. Physiol. 261, 111057 (2021)
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