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AdipoGen Life Sciences
BIX 01294
40
CHF
CHF 40.00
In stock
AG-CR1-0051-M0011 mgCHF 40.00
AG-CR1-0051-M0055 mgCHF 85.00
AG-CR1-0051-M02525 mgCHF 340.00
| Product Details | |
|---|---|
| Synonyms | 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]4-quinazolinamine |
| Product Type | Chemical |
| Properties | |
| Formula |
C28H38N6O2 |
| MW | 490.6 |
| CAS | 935693-62-2 |
| Purity Chemicals | ≥98% (NMR, HPLC) |
| Appearance | White to off-white solid. |
| Solubility | Soluble in DMSO (5 mg/ml), 100% ethanol or dimethyl formamide. |
| Identity | Determined by MS, 1H- and 13C-NMR. |
| InChi Key | OSXFATOLZGZLSK-UHFFFAOYSA-N |
| Smiles | [H][C@]12[C@H](C[C@@H](C)C=C1C=C[C@H](C)[C@@H]2CC[C@@H]1C[C@@H](O)CC(=O)O1)OC(=O)[C@@H](C)CC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Selective and cell permeable G9a [Euchromatic Histone-lysine MethylTransferases EHMT2] histone-lysine methyltransferase (HMTase) inhibitor [1].
- Does not compete with cofactor S-adenosylmethionine [1].
- Pluripotent stem cell inducer [2, 3].
Product References
- Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase: S. Kubicek, et al.; Mol. Cell 25, 473 (2007)
- Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds: Y. Shi, et al.; Cell Stem Cell 3, 568 (2008)
- Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach: J.R. Plews, et al.; PLoS One 5, e14397 (2010)
- Druggable epigenetic suppression of interferon-induced chemokine expression linked to MYCN amplification in neuroblastoma: J. A. Seier, et al.; J. Immunother. Cancer 9, e001335 (2021)
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