BIX 01294 . trihydrochloride

More Information
Product Details
Synonyms	2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]4-quinazolinamine . 3HCl
Product Type	Chemical
Properties
Formula	C₂₈H₃₈N₆O₂ . 3HCl
MW	490.6 . 109.4
CAS	1392399-03-9 \| 935693-62-2 (free base)
Purity Chemicals	≥98% (NMR, HPLC)
Appearance	White to off-white solid.
Solubility	Soluble in DMSO (5 mg/ml) or 100% ethanol.
Identity	Determined by MS, ¹H- and ¹³C-NMR.
InChi Key	FMURUEPQXKJIPS-UHFFFAOYSA-N
Smiles	COC1=C(OC)C=C2C(NC3CCN(CC4=CC=CC=C4)CC3)=NC(=NC2=C1)N1CCCN(C)CC1
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep under inert gas. Protect from light.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Description

Selective and cell permeable G9a histone-lysine methyltransferase (HMTase) inhibitor [1].
Does not compete with cofactor S-adenosylmethionine [1].
Pluripotent stem cell inducer [2, 3].

Product References

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase: S. Kubicek, et al.; Mol. Cell 25, 473 (2007)
Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds: Y. Shi, et al.; Cell Stem Cell 3, 568 (2008)
Activation of pluripotency genes in human fibroblast cells by a novel mRNA based approach: J.R. Plews, et al.; PLoS One 5, e14397 (2010)

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