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AdipoGen Life Sciences
Bisindolylmaleimide IX . methanesulfonate
80
CHF
CHF 80.00
In stock
AG-CR1-0111-M0011 mgCHF 80.00
AG-CR1-0111-M0055 mgCHF 240.00
| Product Details | |
|---|---|
| Synonyms | Ro 31-8220; BIM IX |
| Product Type | Chemical |
| Properties | |
| Formula |
C25H23N5O2S . CH4O3S |
| MW | 457.6 . 96.1 |
| CAS | 138489-18-6 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Red solid. |
| Solubility | Soluble in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | SAWVGDJBSPLRRB-UHFFFAOYSA-N |
| Smiles | CS(O)(=O)=O.CN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CN(CCCSC(N)=N)C2=C1C=CC=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Selective and cell permeable protein kinase C (PKC) inhibitor [1, 2, 3].
- Inhibits the stimulation of insulin secretion by glucose [4, 11].
- Inhibits T cell activation [5].
- Apoptosis inducer [6, 8, 9,10, 13].
- Potent glycogen synthase kinase-3 (GSK-3) inhibitor [7].
- Transcription inhibitor [9].
- Induces TNF receptor family-mediated cell death [10].
- Pim-1 kinase inhibitor [12].
- Antitumor compound [13].
Product References
- Potent selective inhibitors of protein kinase C: P.D. Davis, et al.; FEBS Lett. 259, 61 (1989)
- RO 31-8220 and RO 31-7549 show improved selectivity for protein kinase C over staurosporine in macrophages: P. Dieter & E. Fitzke; BBRC 181, 396 (1991)
- Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C: S.E. Wilkinson, et al.; Biochem. J. 294, 335 (1993)
- Inhibition of glucose-stimulated insulin secretion by Ro 31-8220, a protein kinase C inhibitor: S.J. Persaud & P.M. Jones; Endocrine 3, 285 (1995)
- RO 31-8220, a novel protein kinase C inhibitor, inhibits early and late T cell activation events: L. Geiselhart, et al.; Transplantation 61, 1637 (1996)
- Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3: L. Shen & R.I. Glazer; Biochem. Pharmacol. 55, 1711 (1998)
- The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity: I. Hers, et al.; FEBS Lett. 460, 433 (1999)
- The staurosporine analog, Ro-31-8220, induces apoptosis independently of its ability to inhibit protein kinase C: Z. Han, et al.; Cell Death Differ. 7, 521 (2000)
- Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription: O.W. Rokhlin, et al.; J. Biol. Chem. 277, 33213 (2002)
- Bisindolylmaleimide IX Induces Reversible and Time-Dependent Tumor Necrosis Factor Receptor Family-Mediated Caspase Activation and Cell Death: O.W. Rokhlin & M.B. Cohen; Cancer Biol. Ther. 2, 266 (2003)
- Protein kinase C-independent effects of protein kinase D3 in glucose transport in L6 myotubes: J. Chen, et al.; Mol. Pharmacol. 67, 152 (2005)
- Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002: M.D. Jacobs, et al.; J. Biol. Chem. 280, 13728 (2005)
- Bisindolylmaleimide IX facilitates extrinsic and initiates intrinsic apoptosis in TNF-alpha-resistant human colon adenocarcinoma COLO 205 cells: B. Pajak, et al.; Apoptosis 13, 509 (2008)
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