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AdipoGen Life Sciences
Bisindolylmaleimide III
80
CHF
CHF 80.00
In stock
AG-CR1-0112-M0011 mgCHF 80.00
AG-CR1-0112-M0055 mgCHF 240.00
| Product Details | |
|---|---|
| Synonyms | BIM III |
| Product Type | Chemical |
| Properties | |
| Formula |
C23H20N4O2 |
| MW | 384.4 |
| CAS | 137592-43-9 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Red solid. |
| Solubility | Soluble in methanol or DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | APYXQTXFRIDSGE-UHFFFAOYSA-N |
| Smiles | NCCCN1C=C(C2=C1C=CC=C2)C1=C(C(=O)NC1=O)C1=CNC2=C1C=CC=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent and selective protein kinase C (PKC) inhibitor [1-3].
- Inhibits panel of protein kinases (e.g. GSK-3β, CDK2) [4, 5].
Product References
- The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C: D. Toullec, et al.; J. Biol. Chem. 266, 15771 (1991)
- Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides: P.D. Davis, et al.; J. Med. Chem. 35, 177 (1992)
- Protein kinase C inhibitors; structure-activity relationships in K252c- related compounds: S. Fabre & M. Prudhomme; Bioorg. Med. Chem. 1, 193 (1993)
- Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors: D. Brehmer, et al.; Mol. Cell Proteomics 3, 490 (2004)
- An immuno-chemo-proteomics method for drug target deconvolution: C. Saxena, et al.; J. Proteome Res. 7, 3490 (2008)
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