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AdipoGen Life Sciences
C646
40
CHF
CHF 40.00
In stock
AG-CR1-3508-M0011 mgCHF 40.00
AG-CR1-3508-M0055 mgCHF 105.00
| Product Details | |
|---|---|
| Synonyms | (E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid |
| Product Type | Chemical |
| Properties | |
| Formula |
C24H19N3O6 |
| MW | 445.4 |
| CAS | 328968-36-1 |
| Purity Chemicals | ≥98% (NMR) |
| Appearance | Red solid. |
| Solubility | Soluble in DMSO (10mg/ml). |
| Identity | Determined by 1H-NMR. Mixture of isomers E/Z ~ 4:1. |
| InChi Key | HEKJYZZSCQBJGB-XDHOZWIPSA-N |
| Smiles | CC1=NN(C(=O)\C1=C\C1=CC=C(O1)C1=CC(C)=C(C)C=C1[N+]([O-])=O)C1=CC=C(C=C1)C(O)=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep under inert gas. Protect from light. |
| Use/Stability |
Stable for at least 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Reversible cell permeable p300/CBP histone acetyltransferase (HAT) inhibitor.
- Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<10%).
- Cell growth inhibitor in melanoma and non-small-cell-lung (NSCL) human cancer cell lines.
Product References
- Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor: E.M. Bowers, et al.; Chem. Biol. 17, 471 (2010)
- HAT Trick: p300, Small Molecule, Inhibitor: M. Ott & E. Verdin; Chem. Biol. 17, 417 (2010)
- Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetics remodeling and the expression of pluripotency-associated genes: P. Mali, et al.; Stem Cells 28, 713 (2010)
- Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP: N.T. Crump, et al.; PNAS 108, 7814 (2011)
- Paradoxical Enhancement of Fear Extinction Memory and Synaptic Plasticity by Inhibition of the Histone Acetyltransferase p300: R. Marek, et al.; J. Neurosci. 31, 7486 (2011)
- Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell lines: F.R. Santer, et al.; Mol. Cancer Ther. 10, 1644 (2011)
- Histone-deacetylase-inhibitory effects of periodontopathic-bacterial metabolites induce human gingival epithelial Ca9-22 cell death: K. Uemichi, et al.; Odontology ahead of print (2022)
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