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AdipoGen Life Sciences
Colcemid
40
CHF
CHF 40.00
In stock
AG-CR1-3567-M0011 mgCHF 40.00
AG-CR1-3567-M0055 mgCHF 115.00
| Product Details | |
|---|---|
| Synonyms | Demecolcine; BRN 2822892 |
| Product Type | Chemical |
| Properties | |
| Formula |
C21H25NO5 |
| MW | 371.4 |
| Merck Index | 14: 2887 |
| CAS | 477-30-5 |
| Source/Host Chemicals | Semisynthetic from colchicine (Prod. No. AG-CN2-0048). |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white/light yellow powder. |
| Solubility | Soluble in ethanol, DMSO or chloroform. |
| Identity | Determined by 1H-NMR. |
| InChi Key | NNJPGOLRFBJNIW-HNNXBMFYSA-N |
| Smiles | O=C1C(OC)=CC=C(C([C@@H](NC)CC2)=C1)C3=C2C=C(OC)C(OC)=C3OC |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Anti-cancer compound [2, 6, 7, 10, 11, 14].
- Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle [11, 12, 14].
- Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation) [1, 4, 5, 14].
- Inhibits mitosis during cell division at metaphase by inhibiting spindle formation [2, 5, 7, 8, 14].
- Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center [14].
- Apoptosis inducer [9, 13].
- Thrombopoietic agent [3].
Product References
- Effect of colcemid on fibroblast motility: M.H. Gail & C.W. Boone; Exp. Cell Res. 65, 221 (1971)
- Mitosis in human leukemic leukocytes during colcemid inhibition and recovery: M. McGill & B. R. Brinkley; Cancer Res. 32, 746 (1972)
- The effects of colcemid on hematopoiesis in the mouse: P.A. Bunn Jr., et al.; J. Clin. Invest. 58, 1280 (1976)
- Colcemid and colchicine binding to tubulin. Similarity and dissimilarity: A.C. Banerjee & B. Bhattacharyya; FEBS Lett. 99, 333 (1979)
- Comparison of mitostatic effect, cell uptake and tubulin-binding activity on colchicine and colcemid: A.S. Serpinskaya, et al.; Biochim. Biophys. Acta 673, 86 (1981)
- Action of demecolcine (colcemid) in the murine sarcoma 180 tumor: T. Nomura & J.E. Plager; Cancer Treat. Rep. 65, 283 (1981)
- Colcemid effects on B16 melanoma cell progression and aberrant mitotic division: B.K. Bhuyan, et al.; J. Cell Physiol. 132, 237 (1987)
- Colcemid and the mitotic cycle: C.L. Rieder & R.E. Palazzo; J. Cell. Sci. 102, 387 (1992)
- Induction of apoptosis by the anti-tubulin drug colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells: S.W. Sherwood, et al.; Exp. Cell. Res. 215, 373 (1994)
- Effects of colcemid concentration on chromosome aberration analysis in human lymphocytes: R. Kanda, et al.; J. Radiat. Res. (Tokyo) 35, 41 (1994)
- Cell cycle arrest by Colcemid differs in human normal and tumor cells: M.N. Jha, et al.; Cancer Res. 54, 5011 (1994)
- Dissociation of nuclear and cytoplasmic cell cycle progression by drugs employed in cell synchronization: L. Urbani, et al.; Exp. Cell. Res. 219, 159 (1995)
- Expression of apoptosis and cell cycle related genes in proliferating and colcemid arrested cells of divergent lineage: B.W. Gallaher, et al.; Cell. Mol. Biol. 46, 79 (2000)
- Inhibition of Cell Migration and Cell Division Correlates with Distinct Effects of Microtubule Inhibiting Drugs: H. Yang, et al.; J. Biol. Chem. 285, 32242 (2010)
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