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AdipoGen Life Sciences
DETA NONOate
40
CHF
CHF 40.00
In stock
AG-CR1-3614-M0055 mgCHF 40.00
AG-CR1-3614-M02525 mgCHF 140.00
| Product Details | |
|---|---|
| Synonyms | DETA/NO; Diethylenetriamine NONOate; NOC-18; 2,2'-(Hydroxynitrosohydrazono)bis-ethanamine |
| Product Type | Chemical |
| Properties | |
| Formula |
C4H13N5O2 |
| MW | 163.2 |
| CAS | 146724-94-9 |
| RTECS | KH2502500 |
| Purity Chemicals | ≥98% |
| Appearance | White to off-white solid. |
| Solubility | Soluble in water. |
| Other Product Data |
UV absorbance: 252nm (ε = 7.640M-1cm-1) |
| InChi Key | PAOXTYJXTPPVHU-UHFFFAOYSA-O |
| Smiles | NCCN(CC[NH3+])N([O-])N=O |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice |
Keep under inert gas. Protect from moisture. |
| Use/Stability | Stable for at least 1 year after receipt when stored at -80°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Nitric oxide (NO) donor. The slow release of NO allows the use in experiments investigating the effects of prolonged constant NO delivery to cells and tissues.
- The half-life time is 20 hours at 37°C and 56 hours at 22-25°C in 0.1M phosphate buffer, pH 7.4. Liberates 2 mol of NO per mol of parent compound. Decomposition of NONOates is nearly instantaneous at pH 5.0.
Product References
- New nitric oxide-releasing zwitterions derived from polyamines: J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993)
- Nitric oxide/nucleophile complexes: a unique class of nitric oxide-based vasodilators: L.K. Keefer & D. Morley; J. Cardiovasc. Pharmacol. 22, 3 (1993)
- Intracerebroventricular administration of a nitric oxide-releasing compound, NOC-18, produces thermal hyperalgesia in rats: S. Shibuta, et al.; Neurosci. Lett. 187, 103 (1995)
- NOC, a nitric-oxide-releasing compound, induces dose dependent apoptosis in macrophages: M. Shimaoka, et al.; BBRC 209, 519 (1995)
- Nitric oxide (NO) donor molecules: effect of NO release rate on vascular smooth muscle cell proliferation in vitro: D.L. Mooradian, et al.; J. Cardiovasc. Pharmacol. 25, 674 (1995)
- NONOates (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms: L.K. Keefer, et al.; Methods Enzymol. 268, 281 (1996)
- The nitric oxide donor DETA-NONOate decreases matrix metalloproteinase-9 expression and activity in rat aortic smooth muscle and abdominal aortic explants: I. Sinha, et al.; Ann. Vasc. Surg. 20, 92 (2006)
- In vitro and in vivo sensitization of SW620 metastatic colon cancer cells to CDDP-induced apoptosis by the nitric oxide donor DETANONOate: Involvement of AIF: S. Huerta, et al.; Nitric Oxide 20, 182 (2009)
- Neuroprotective effects of nitric oxide donor NOC-18 against brain ischemia-induced mitochondrial damages: role of PKG and PKC: O. Arandarcikaite, et al.; Neurosci. Lett. 586, 65 (2015)
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