DETA NONOate

CHF 40.00
In stock
AG-CR1-3614-M0055 mgCHF 40.00
AG-CR1-3614-M02525 mgCHF 140.00
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Product Details
Synonyms DETA/NO; Diethylenetriamine NONOate; NOC-18; 2,2'-(Hydroxynitrosohydrazono)bis-ethanamine
Product Type Chemical
Properties
Formula

C4H13N5O2

MW 163.2
CAS 146724-94-9
RTECS KH2502500
Purity Chemicals ≥98%
Appearance White to off-white solid.
Solubility Soluble in water.
Other Product Data

UV absorbance: 252nm (ε = 7.640M-1cm-1)

InChi Key PAOXTYJXTPPVHU-UHFFFAOYSA-O
Smiles NCCN(CC[NH3+])N([O-])N=O
Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -80°C
Handling Advice Keep under inert gas.
Protect from moisture.
Use/Stability Stable for at least 1 year after receipt when stored at -80°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Nitric oxide (NO) donor. The slow release of NO allows the use in experiments investigating the effects of prolonged constant NO delivery to cells and tissues.
  • The half-life time is 20 hours at 37°C and 56 hours at 22-25°C in 0.1M phosphate buffer, pH 7.4. Liberates 2 mol of NO per mol of parent compound. Decomposition of NONOates is nearly instantaneous at pH 5.0.
Product References
  1. New nitric oxide-releasing zwitterions derived from polyamines: J.A. Hrabie, et al.; J. Org. Chem. 58, 1472 (1993)
  2. Nitric oxide/nucleophile complexes: a unique class of nitric oxide-based vasodilators: L.K. Keefer & D. Morley; J. Cardiovasc. Pharmacol. 22, 3 (1993)
  3. Intracerebroventricular administration of a nitric oxide-releasing compound, NOC-18, produces thermal hyperalgesia in rats: S. Shibuta, et al.; Neurosci. Lett. 187, 103 (1995)
  4. NOC, a nitric-oxide-releasing compound, induces dose dependent apoptosis in macrophages: M. Shimaoka, et al.; BBRC 209, 519 (1995)
  5. Nitric oxide (NO) donor molecules: effect of NO release rate on vascular smooth muscle cell proliferation in vitro: D.L. Mooradian, et al.; J. Cardiovasc. Pharmacol. 25, 674 (1995)
  6. NONOates (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms: L.K. Keefer, et al.; Methods Enzymol. 268, 281 (1996)
  7. The nitric oxide donor DETA-NONOate decreases matrix metalloproteinase-9 expression and activity in rat aortic smooth muscle and abdominal aortic explants: I. Sinha, et al.; Ann. Vasc. Surg. 20, 92 (2006)
  8. In vitro and in vivo sensitization of SW620 metastatic colon cancer cells to CDDP-induced apoptosis by the nitric oxide donor DETANONOate: Involvement of AIF: S. Huerta, et al.; Nitric Oxide 20, 182 (2009)
  9. Neuroprotective effects of nitric oxide donor NOC-18 against brain ischemia-induced mitochondrial damages: role of PKG and PKC: O. Arandarcikaite, et al.; Neurosci. Lett. 586, 65 (2015)
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