AdipoGen Life Sciences


CHF 60.00
In stock
AG-MR-C0029-M0011 mgCHF 60.00
AG-MR-C0029-M0055 mgCHF 180.00
AG-MR-C0029-M02525 mgCHF 540.00
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Product Details
Synonyms 6AP
Product Type Chemical


MW 194.2
CAS 832-68-8
Purity Chemicals ≥97% (HPLC)
Appearance Beige solid.
Solubility Soluble in DMSO or ethanol.
Reconstitution Stock solutions can be made up to 10mM in DMSO.
Identity Determined by 1H-NMR.
Smiles NC1=NC2=C(C=CC=C2)C2=C1C=CC=C2
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Antiprion agent.
  • Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome.
  • Inhibitor of protein aggregation.
Product References
  1. An expeditious synthesis of 6-aminophenanthridines: F. Gug, et al.; THL 46, 3725 (2005)
  2. Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs: D. Tribouillard-Tanvier, et al.; PLoS One 3, e2174 (2008)
  3. Tools for the study of ribosome-borne protein folding activity: C. Voisset, et al.; Biotechnol. J. 3, 1033 (2008)
  4. Mode of action of the antiprion drugs 6AP and GA on ribosome assisted protein folding: S.D. Reis, et al.; Biochimie 93, 1047 (2011)
  5. Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy: N. Barbezier, et al.; EMBO Mol. Med. 3, 35 (2011)
  6. The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition: Y. Pang, et al.; J. Biol. Chem. 288, 19081 (2013)
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