Cookie Policy: This site uses cookies to improve your experience. You can find out more about our use of cookies in our Privacy Policy. By continuing to browse this site you agree to our use of cookies.
AdipoGen Life Sciences
6-Aminophenanthridine
60
CHF
CHF 60.00
In stock
AG-MR-C0029-M0011 mgCHF 60.00
AG-MR-C0029-M0055 mgCHF 180.00
AG-MR-C0029-M02525 mgCHF 540.00
| Product Details | |
|---|---|
| Synonyms | 6AP |
| Product Type | Chemical |
| Properties | |
| Formula |
C13H10N2 |
| MW | 194.2 |
| CAS | 832-68-8 |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Beige solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Reconstitution | Stock solutions can be made up to 10mM in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | FVCXJXKLDUJOFA-UHFFFAOYSA-N |
| Smiles | NC1=NC2=C(C=CC=C2)C2=C1C=CC=C2 |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | After reconstitution, prepare aliquots and store at -20°C. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antiprion agent.
- Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome.
- Inhibitor of protein aggregation.
Product References
- An expeditious synthesis of 6-aminophenanthridines: F. Gug, et al.; THL 46, 3725 (2005)
- Protein folding activity of ribosomal RNA is a selective target of two unrelated antiprion drugs: D. Tribouillard-Tanvier, et al.; PLoS One 3, e2174 (2008)
- Tools for the study of ribosome-borne protein folding activity: C. Voisset, et al.; Biotechnol. J. 3, 1033 (2008)
- Mode of action of the antiprion drugs 6AP and GA on ribosome assisted protein folding: S.D. Reis, et al.; Biochimie 93, 1047 (2011)
- Antiprion drugs 6-aminophenanthridine and guanabenz reduce PABPN1 toxicity and aggregation in oculopharyngeal muscular dystrophy: N. Barbezier, et al.; EMBO Mol. Med. 3, 35 (2011)
- The antiprion compound 6-aminophenanthridine inhibits the protein folding activity of the ribosome by direct competition: Y. Pang, et al.; J. Biol. Chem. 288, 19081 (2013)
Related Products
