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AdipoGen Life Sciences
6-Amino-8-trifluoromethylphenanthridine
75
CHF
CHF 75.00
In stock
AG-MR-C0031-M0011 mgCHF 75.00
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AG-MR-C0031-M02525 mgCHF 675.00
| Product Details | |
|---|---|
| Synonyms | 6A-8tFP; 8-Trifluoromethyl-6-aminophenanthridine |
| Product Type | Chemical |
| Properties | |
| Formula |
C14H9F3N2 |
| MW | 262.2 |
| CAS | 651055-83-3 |
| Purity Chemicals | ≥99% (NMR) |
| Appearance | Beige solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Reconstitution | Stock solutions can be made up to 10mM in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | VBQYJKNVRUTAHL-UHFFFAOYSA-N |
| Smiles | NC1=NC2=C(C=CC=C2)C2=C1C=C(C=C2)C(F)(F)F |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | After reconstitution, prepare aliquots and store at -20°C. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Potent antiprion agent. Higher activity than 6-Aminophenanthridine (Prod. No. MC-C0029).
- Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome.
- Inhibitor of protein aggregation.
Product References
- Isolation of drugs active against mammalian prions using a yeast-based screening assay: S. Bach, et al.; Nat. Biotechnol. 21, 1075 (2003)
- A single step synthesis of 6-aminophenanthridines from anilines and 2-chlorobenzonitriles: F. Gug, et al.; THL 60, 4705 (2004)
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