6-Amino-8-trifluoromethylphenanthridine

CHF 75.00
In stock
AG-MR-C0031-M0011 mgCHF 75.00
AG-MR-C0031-M0055 mgCHF 225.00
AG-MR-C0031-M02525 mgCHF 675.00
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Product Details
Synonyms 6A-8tFP; 8-Trifluoromethyl-6-aminophenanthridine
Product Type Chemical
Properties
Formula

C14H9F3N2

MW 262.2
CAS 651055-83-3
Purity Chemicals ≥99% (NMR)
Appearance Beige solid.
Solubility Soluble in DMSO or ethanol.
Reconstitution Stock solutions can be made up to 10mM in DMSO.
Identity Determined by 1H-NMR.
InChi Key VBQYJKNVRUTAHL-UHFFFAOYSA-N
Smiles NC1=NC2=C(C=CC=C2)C2=C1C=C(C=C2)C(F)(F)F
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Potent antiprion agent. Higher activity than 6-Aminophenanthridine (Prod. No. MC-C0029).
  • Ribosome-borne protein folding activity (RPFA) inhibitor. Binds to the ribosomal RNA and inhibits specifically the protein folding activity of the ribosome.
  • Inhibitor of protein aggregation.
Product References
  1. Isolation of drugs active against mammalian prions using a yeast-based screening assay: S. Bach, et al.; Nat. Biotechnol. 21, 1075 (2003)
  2. A single step synthesis of 6-aminophenanthridines from anilines and 2-chlorobenzonitriles: F. Gug, et al.; THL 60, 4705 (2004)
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