Chloroguanabenz . acetate

CHF 80.00
In stock
AG-MR-C0036-M0011 mgCHF 80.00
AG-MR-C0036-M0055 mgCHF 320.00
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Product Details
Synonyms 1-[(E)-2,3,6-Trichlorophenylmethyleneamino]guanidine; Hydrazinecarboximidamide, 2-[(2,3,6-trichlorophenyl)methylene]-; Guanabenz; Chlorine-Guanabenz
Product Type Chemical
Properties
Formula

C8H7Cl3N4 . C2H4O2

MW 265.5 . 60.1
CAS 23113-55-5
Purity Chemicals ≥95% (NMR)
Appearance White to off-white powder.
Solubility Soluble in DMSO or ethanol.
Reconstitution Stock solutions can be made up to 10mM in DMSO.
Identity Determined by 1H-NMR.
InChi Key DFBSKPLTAXXMPH-LAJPFITQSA-M
Smiles CC(=N)N\N=C\C1=C(Cl)C=CC(Cl)=C1Cl
Shipping and Handling
Shipping AMBIENT
Short Term Storage +4°C
Long Term Storage -20°C
Handling Advice After reconstitution, prepare aliquots and store at -20°C.
Use/Stability Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS Download PDF
Product Specification Sheet
Datasheet Download PDF
  • Antiprion agent.
  • Inhibitor of protein aggregation.
  • Specifically reduces accumulation of a pathogenic fragment of Huntingtin in a transiently transfected cellular model of Huntington’s disease (HD).
  • Tool for treating HD and other polyglutamine expansion associated diseases.
Product References
  1. Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions: D. Tribouillard-Tanvier, et al.; PLoS One 3, e1981 (2008)
  2. Use of chlorine guanabenz derivatives for treating polyglutamine expansion associated diseases: A. Bertolotti & M. Blondel; Patent WO002008041133A2 (2008)
  3. Synthesis of conjugates of 6-aminophenanthridine and guanabenz, two structurally unrelated prion inhibitors, for the determination of their cellular targets by affinity chromatography: F. Gug, et al.; Bioconjug. Chem. 21, 279 (2010)
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