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AdipoGen Life Sciences
Chloroguanabenz . acetate
80
CHF
CHF 80.00
In stock
AG-MR-C0036-M0011 mgCHF 80.00
AG-MR-C0036-M0055 mgCHF 320.00
| Product Details | |
|---|---|
| Synonyms | 1-[(E)-2,3,6-Trichlorophenylmethyleneamino]guanidine; Hydrazinecarboximidamide, 2-[(2,3,6-trichlorophenyl)methylene]-; Guanabenz; Chlorine-Guanabenz |
| Product Type | Chemical |
| Properties | |
| Formula |
C8H7Cl3N4 . C2H4O2 |
| MW | 265.5 . 60.1 |
| CAS | 23113-55-5 |
| Purity Chemicals | ≥95% (NMR) |
| Appearance | White to off-white powder. |
| Solubility | Soluble in DMSO or ethanol. |
| Reconstitution | Stock solutions can be made up to 10mM in DMSO. |
| Identity | Determined by 1H-NMR. |
| InChi Key | DFBSKPLTAXXMPH-LAJPFITQSA-M |
| Smiles | CC(=N)N\N=C\C1=C(Cl)C=CC(Cl)=C1Cl |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | After reconstitution, prepare aliquots and store at -20°C. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- Antiprion agent.
- Inhibitor of protein aggregation.
- Specifically reduces accumulation of a pathogenic fragment of Huntingtin in a transiently transfected cellular model of Huntington’s disease (HD).
- Tool for treating HD and other polyglutamine expansion associated diseases.
Product References
- Antihypertensive drug guanabenz is active in vivo against both yeast and mammalian prions: D. Tribouillard-Tanvier, et al.; PLoS One 3, e1981 (2008)
- Use of chlorine guanabenz derivatives for treating polyglutamine expansion associated diseases: A. Bertolotti & M. Blondel; Patent WO002008041133A2 (2008)
- Synthesis of conjugates of 6-aminophenanthridine and guanabenz, two structurally unrelated prion inhibitors, for the determination of their cellular targets by affinity chromatography: F. Gug, et al.; Bioconjug. Chem. 21, 279 (2010)
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