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Figure 1: 5x10^5 cultured Jurkat cells were washed and incubated 45 min on ice with 80µl of anti-TCR Cβ1/PF at 5µg/ml. Cells were washed twice and incubated with 2nd reagent as described above, after they were washed three times, fixed and analyzed by FACS. Cells stained positive with a mean shift of 1.03 log10 fluorescent units when compared to a Mouse IgG2a negative control (ANC-281-810) at a similar concentration.
Human T cell receptor (TCR) is a T cell surface expressed heterodimer of α/β or γ/δ chains. TCR’s recognize antigen peptides bound to MHC molecules forming the basis of antigen specific response by T cells. This specific TRBC1 antibody has been described to be useful in a simplified immunophenotypic assessment of T cell clonality.
Product References
Generation of monoclonal antibodies against a human T cell receptor beta chain expressed in transgenic mice: J.L. Viney, et al.; Hybridoma 11, 701 (1992)
T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases: A. Weiss, et al.; Cell 73, 209 (1993)
Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies: P.M. Maciocia, et al.; Nat. Med. 23, 1416 (2017)
Single Antibody Detection of T-Cell Receptor αβ Clonality by Flow Cytometry Rapidly Identifies Mature T-Cell Neoplasms and Monotypic Small CD8-Positive Subsets of Uncertain Significance: M. Shi, et al.; Cytometry B Clin. Cytom. 98, 99 (2020)
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