anti-TCR Cβ1 (human), mAb (Jovi-1)

CHF 319.00
In stock
ANC-101-020100 µgCHF 319.00
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Product Details
Synonyms TCRB; T Cell Receptor β Locus; TRBC1
Product Type Monoclonal Antibody
Properties
Clone Jovi-1 [also called Jovi.1]
Isotype Mouse IgG2a
Source/Host Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen Human HA1.7 TCR beta chain expressed on transgenic mouse cells.
Application

Flow Cytometry (1:50)

FUNC: Mitogenic for T cells expressing TCR Cβ1.

IHC: (see P.M. Maciocia, et al.; Nat. Med. 23, 1416 (2017))

Crossreactivity Human
Specificity

Recognizes human Cβ1 TCR gene product (TRBC1) and reacts with 50-75% of T cells in normal human blood. Does not bind to TCR Cβ2 (TRBC2).

Purity ≥95% (SDS-PAGE)
Purity Detail Protein A purified.
Formulation 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 0.5% Gentamicin sulfate
Isotype Negative Control

Mouse IgG2a Isotype Control

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by Ancell Corporation.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF

Human T cell receptor (TCR) is a T cell surface expressed heterodimer of α/β or γ/δ chains. TCR’s recognize antigen peptides bound to MHC molecules forming the basis of antigen specific response by T cells. This specific TRBC1 antibody has been described to be useful in a simplified immunophenotypic assessment of T cell clonality.

Product References
  1. Generation of monoclonal antibodies against a human T cell receptor beta chain expressed in transgenic mice: J.L. Viney, et al.; Hybridoma 11, 701 (1992)
  2. T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases: A. Weiss, et al.; Cell 73, 209 (1993)
  3. Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies: P.M. Maciocia, et al.; Nat. Med. 23, 1416 (2017)
  4. Single Antibody Detection of T-Cell Receptor αβ Clonality by Flow Cytometry Rapidly Identifies Mature T-Cell Neoplasms and Monotypic Small CD8-Positive Subsets of Uncertain Significance: M. Shi, et al.; Cytometry B Clin. Cytom. 98, 99 (2020)
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