Ancell

anti-CD47 (human), mAb (ANC2F6) (Biotin)

CHF 306.00
In stock
ANC-198-030100 µgCHF 306.00
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Product Details
Synonyms IAP; Integrin Associated Protein; Leukocyte Surface Antigen CD47
Product Type Monoclonal Antibody
Properties
Clone ANC2F6
Isotype Mouse IgG1κ
Source/Host Purified from concentrated hybridoma tissue culture supernatant.
Immunogen/Antigen Recombinant human CD47 (extracellular Ig domain).
Label/Conjugates Biotin
Application

ELISA

Flow Cytometry

Crossreactivity Human
Specificity

Binds to an epitope within the extracellular Ig-like domain of human CD47.

Purity ≥95% (SDS-PAGE)
Purity Detail Protein A purified.
Formulation 50 mM Sodium Phosphate pH 7.5, 100 mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2%BSA, 0.04% sodium azide.
Isotype Negative Control

Mouse IgG1 Isotype Control (Biotin)

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Accession Number Q08722
Declaration Manufactured by Ancell Corporation.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 1 year after receipt when stored at +4°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

Human CD47 (IAP; Integrin Associated Protein) is a broadly expressed Ig superfamily glycoprotein of about 50kD with a long extracellular Ig like domain, 5 transmembrane domains and an alternatively spliced intracellular C-terminal domain. It interacts with its ligand SIRPα (CD172a; Signal Regulatory Protein) expressed mainly on myeloid cells serving as a negative immune regulator, inhibiting phagocytosis. The CD47-SIRPα axis is being investigated as possible anti-tumor immune intervention point. Blockade of this interaction has shown promise in models of HNSCC, glioma and breast cancer.

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