Ancell

CD123 [IL-3Rα] (human)-muIg Fusion Protein (Biotin)

CHF 669.00
In stock
ANC-545-03025 µgCHF 669.00
More Information
Product Details
Synonyms Interleukin-3 Receptor α
Product Type Protein
Properties
Source/Host CHO cells
Sequence

A soluble molecule consisting of the extracellular domain of mature human CD123 fused to murine IgG2a Fc.

Crossreactivity Human
Application

ELISA

Label/Conjugates Biotin
Purity Detail Protein A and SEC purified.
Concentration 0.5mg/ml
Accession Number P26951
Formulation 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl, 5% Glycerol, 0.2% BSA, 0.04% Sodium Azide.
Protein Negative Control

MuIg Control Protein

Other Product Data

Click here for Original Manufacturer Product Datasheet
Our product description may differ slightly from the original manufacturers product datasheet.

Declaration Manufactured by Ancell Corporation.
Shipping and Handling
Shipping BLUE ICE
Short Term Storage +4°C
Long Term Storage +4°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 6 months after receipt when stored at +4°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

Human CD123 (Interleukin-3 Receptor α) is a 70kDa type I transmembrane molecule, and is the low affinity receptor for the cytokine IL-3, which can stimulate proliferation or differentiation. When paired in a heterodimer with CD131 (IL-3Rβ), it binds IL-3 with much higher affinity. CD123 is found on myeloid precusors, stem cells, a subset of T cells, some B cells, megakaryocytes, basophils, monocytes and epithelial cells. CD123 is present at high levels on many hematologic malignancies, and antibodies and CAR T cells against CD123 have been used successfully to combat acute myeloid leukemia (AML).

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