PARG (human) (rec.) (His) (active) (1µg)

Specifications / Handling

More Information
Product Details
Synonyms	Poly(ADP-ribose) Glycohydrolase
Product Type	Protein
Properties
Source/Host	Baculovirus system
Sequence	Recombinant human PARG enzyme (aa1-976) fused to a C-terminal His-tag.
Crossreactivity	Human
Biological Activity	The enzyme has been thoroughly validated with Transcreener ADPR Activity Assays. For specific activity please refer to the Certificate of Analysis for each individual enzyme lot.
MW	111.9kDa
Purity	≥80% (SDS-PAGE)
Accession Number	Q86W56
Formulation	Liquid. In 50mM Tris-HCl pH 7.5, 500mM NaCl, 10% glycerol, 1mM TCEP.
Shipping and Handling
Shipping	DRY ICE
Short Term Storage	-20°C
Long Term Storage	-80°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at -80°C.
Documents
MSDS	Inquire
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. PARG hydrolyzes poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose. PARG plays an important role in DNA damage repair and has been seen as a potential target for anticancer therapy.

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