BellBrook

MDA5 (human) (rec.) (active) (17µg)

CHF 782.00
In stock
BBL-2298-C0171 eaCHF 782.00
More Information
Product Details
Synonyms Helicard; Melanoma Differentiation-associated Gene 5; IFIH1; Interferon Induced with Helicase C Domain 1
Product Type Protein
Properties
Source/Host E. coli
Sequence

Human MDA5 (aa 299-1025).

Crossreactivity Human
Application

For use with Transcreener ADP2assays.

Biological Activity

For the specific activity please refer to the Certificate of Analysis for each individual enzyme lot.

Purity ≥75% (SDS-PAGE)
Accession Number Q9BYX4
Formulation Liquid. In 20mM HEPES pH 7.5, 150mM NaCl, 2mM TCEP, 10% glycerol.
Other Product Data

Uniprot Q9BYX4: MDA5 (human)

Shipping and Handling
Shipping DRY ICE
Short Term Storage -20°C
Long Term Storage -80°C
Handling Advice Avoid freeze/thaw cycles.
Use/Stability Stable for at least 6 months after receipt when stored at -80°C.
Documents
MSDS Inquire
Product Specification Sheet
Datasheet Download PDF
Description

MDA5 is a highly conserved helicase involved in the innate immune response to virus. MDA5, upon interaction with intracellular dsRNA (produced during viral replication), triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-κB, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-β and RANTES (CCL5). MDA5 is widely expressed at low levels. The expression is detected at higher levels in placenta, pancreas and spleen and barely in brain, testis and lung. Genetic variation in MDA5 is associated with diabetes mellitus insulin-dependent type 19 (IDDM19). A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy.

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