BellBrook

PARP2 (human) (rec.) (His) (active) (50µg)

As low as CHF 1’683.00

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BBL-2348-C05050 µgCHF 1’683.00

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Product Details
Synonyms	Poly(ADP-ribose) Polymerase 2; ADP-ribosyltransferase Diphtheria Toxin-like 2; NAD(+) ADP-ribosyltransferase 2; ARTD2; PARP-2
Product Type	Protein
Properties
Source/Host	Insect cells
Sequence	Full-length human PARP2 (aa 1-583) with an N-terminal His-tag.
Crossreactivity	Human
Biological Activity	The enzyme has been thoroughly validated with the Transcreener pADPr Assay Kit.
MW	67.0 kDa
Purity	≥90% (SDS-PAGE)
Accession Number	Q9UGN5
Formulation	Liquid in 50mM TRIS, 500mM NaCl, and 5% Glycerol (pH 8.0).
Other Product Data	Click here for Complete Information from the Original Manufacturer Our product description may differ slightly from the original manufacturer's product datasheet. Uniprot Q9UGN5: PARP2 HUMAN
Shipping and Handling
Shipping	DRY ICE
Short Term Storage	-20°C
Long Term Storage	-80°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at -80°C.
Documents
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

PARP-2 [ARTD2] is a member of the PARP family of enzymes, which transfer ADP-ribose units from NAD⁺ onto target proteins (a process called ADP-ribosylation). PARP-2 detects DNA strand breaks and helps recruit DNA repair machinery. It is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damage and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.

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