WRN Exonuclease (human) (rec.) (His) (active) (5µg)

The WRN protein is a unique member of the RecQ family of DNA helicases distinguished by its dual enzymatic activities: a 3′→5′ DNA helicase and a 3′→5′ exonuclease. The exonuclease activity, located in the N-terminal domain, enables WRN to process DNA ends and plays a critical role in multiple DNA metabolic pathways, including DNA repair, replication, recombination and telomere maintenance. By coordinating unwinding and degradation of DNA, WRN ensures proper resolution of DNA intermediates and preservation of genomic stability. Mutations that disrupt WRN function lead to Werner syndrome, a rare premature aging disorder marked by genomic instability and increased cancer predisposition. The WRN exonuclease is therefore a central player in maintaining genome integrity and a key subject of study in aging, DNA repair, and cancer biology.