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BellBrook
WRN Helicase TR-FRET Assay System
CHF 0.00
In stock
BBL-3032-TR-1K1000 assaysCHF 726.00
BBL-3032-TR-10K10000 assaysCHF 2'609.00
BBL-3032-TR-100K10 x 10000 assaysINQ
Figure 1: Schematic Overview of the WRN Helicase Assay System with the Transcreener® ADP2 Assays.
| Product Details | |
|---|---|
| Synonyms | Werner Syndrome Protein; Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN; DNA Helicase RecQ-like Type 3; RecQ Protein-like 2 |
| Product Type | Kit |
| Properties | |
| Application Set | Compound Screening |
| Crossreactivity | Human |
| Quantity |
1000 assays/384wells (BBL-3032TR-1K) 10000 assays/384wells (BBL-3032TR-10K) 100000 assays/384wells (BBL-3032TR-100K) Note: The exact number of assays depends on enzyme reaction conditions. |
| Detection Type | TR-FRET |
| Kit Contains |
- WRN helicase enzyme (human) (rec.) (His) |
| Other Product Data |
Click here for Complete Information from the Original Manufacturer |
| Declaration | Manufactured by BellBrook Labs. |
| Accession Number | Q14191 |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -20°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Documents | |
| Manual |
 Download PDF |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
WRN helicase inhibitors are sought-after therapeutics for targeting cancers that lack adequate mismatch repair machinery and enhanced mutation at microsatellite repeats (MSI-H). The WRN Helicase Assay System, when used with the Transcreener ADP Assay Kit, provides all reagents required to screen and profile WRN helicase inhibitors.
The WRN Helicase Assay System includes WRN helicase (Werner syndrome helicase) enzyme, substrate, assay plates, and buffers required to measure WRN Helicase's ATPase activity. The Transcreener ADP Assay (sold separately), a far-red competitive assay designed for HTS and inhibitor dose-response measurements, measures ADP produced to determine enzymatic activity.
When purchasing the WRN helicase assay system, it is important to choose the assay system readout corresponding to the TR-FRET configuration of your Transcreener ADP Assay Kit!
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