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BellBrook
VPS4B (human) (rec.) (His) (active) (50µg)
As low as
628
CHF
CHF 628.00
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BBL-2371-C05050 µgCHF 628.00
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| Product Details | |
|---|---|
| Synonyms | Vacuolar Protein Sorting-associated Protein 4B; Suppressor of K(+) transport growth defect 1; Protein SKD1 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence |
Human VSP4B full-length (aa1-444) with an N-terminal 6x His-tag. |
| Crossreactivity | Human |
| Application |
Drug Discovery |
| Biological Activity |
The enzyme has been thoroughly validated with the Transcreener ADP Assay Kit. |
| MW | 51.9kDa |
| Purity | ≥95% (SDS-PAGE) |
| Accession Number | O75351 |
| Formulation | Liquid in 50mM Tris-HCl, 500mM NaCl, 10% Glycerol (pH 8). |
| Other Product Data |
Click here for Complete Information from the Original Manufacturer Uniprot O75351: VPS4B HUMAN |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -80°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
VPS4B (Vacuolar Protein Sorting–Associated Protein 4B) is an ATPase of the AAA+ protein family that plays a critical role in the endosomal sorting pathway. It is an essential component of the ESCRT (Endosomal Sorting Complex Required for Transport) machinery, where it drives the disassembly and recycling of ESCRT-III complexes following membrane scission events. VPS4B is involved in a range of fundamental cellular processes, including multivesicular body (MVB) formation, receptor downregulation, cytokinesis, autophagy, and viral budding. Through ATP hydrolysis, VPS4B provides the energy required to remodel ESCRT assemblies, ensuring proper membrane trafficking and intracellular protein turnover. Dysregulation of VPS4B function has been linked to defects in endosomal trafficking and has implications in cancer biology, neurodegenerative disorders, and viral infection mechanisms. As such, VPS4B is a valuable target for studies of membrane dynamics, cell division, and host-pathogen interactions. This VPS4B product is suitable for use in biochemical assays, structural studies, and cell biology applications investigating ESCRT-mediated membrane remodeling and intracellular transport pathways.
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