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BellBrook
eIF4A3 (human) (rec.) (His) (active) (50µg)
As low as
628
CHF
CHF 628.00
In stock
Only %1 left
BBL-2385-C05050 µgCHF 628.00
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Specifications / Handling
| Product Details | |
|---|---|
| Synonyms | Eukaryotic Initiation Factor 4A-III; DDX48; ATP-dependent RNA Helicase eIF4A-3; Nuclear Matrix Protein 265 |
| Product Type | Protein |
| Properties | |
| Source/Host | E. coli |
| Sequence |
Full-length human eIF4A3 protein with an N-terminal 6x His-tag. |
| Crossreactivity | Human |
| Application |
For use with Transcreener ADP2 assay. |
| Biological Activity |
The enzyme has been thoroughly validated with Transcreener ADP² Activity Assays. For specific activity please refer to the Certificate of Analysis for each individual enzyme lot. |
| MW | ~47.7kDa |
| Purity | ≥85% (SDS-PAGE) |
| Accession Number | P38919 |
| Formulation | Liquid. 50mM Tris-HCl, 150mM NaCl, 0.5M L-Arginine, 10% Glycerol (pH 8). |
| Other Product Data |
Click here for Complete Information from the Original Manufacturer Uniprot P38919: EIF4A3_HUMAN |
| Shipping and Handling | |
| Shipping | DRY ICE |
| Short Term Storage | -20°C |
| Long Term Storage | -80°C |
| Handling Advice | Avoid freeze/thaw cycles. |
| Use/Stability | Stable for at least 6 months after receipt when stored at -80°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Scientific Background Information
Product Description
eIF4A3 is an ATP-dependent RNA helicase of the DEAD-box protein family. Unlike eIF4A1 and eIF4A2, eIF4A3 primarily functions as a core component of the exon junction complex (EJC), which is deposited on mRNA following pre-mRNA splicing. eIF4A3 binds RNA and ATP and acts as an RNA clamp within the EJC together with MAGOH, RBM8A/Y14 and CASC3. Through this complex, eIF4A3 contributes to mRNA processing, nuclear export, localization, translation regulation and nonsense-mediated mRNA decay (NMD). eIF4A3 is therefore widely studied in RNA metabolism, post-transcriptional gene regulation and RNA quality control. Recombinant eIF4A3 is suitable for biochemical studies of RNA binding, ATPase/helicase activity, exon junction complex formation and screening or characterization of eIF4A3 modulators.
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