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BellBrook
EX-527 (SIRT1 Inhibitor)
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535
CHF
CHF 535.00
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BBL-5005-M02525 mgCHF 535.00
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| Product Details | |
|---|---|
| Synonyms | 6-Chloro-2,3,4,9-tetrahydro-1H-carbazole-1-xarboxamide (racemic) |
| Product Type | Chemical |
| Properties | |
| Formula |
C13H13ClN2O |
| MW | 248.7 |
| CAS | 49843-98-3 |
| Purity Chemicals | ≥98% (TLC) |
| Appearance | Light yellow solid. |
| Solubility | Soluble in DMSO (18mg/ml). |
| Identity | Determined by 1H-NMR. |
| InChi Key | FUZYTVDVLBBXDL-UHFFFAOYSA-N |
| Smiles | ClC(C=C1)=CC2=C1NC3=C2CCCC3C(N)=O |
| Shipping and Handling | |
| Shipping | BLUE ICE |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Use/Stability |
Stable for at least 1 year after receipt when stored at +4°C. Stock solutions are stable for at least 3 months when stored at -20°C. |
| Documents | |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
EX-527 is a SIRT1 inhibitor that has been fully validated using the Transcreener OAADPr SIRT Assay and Enzolution SIRT1 Assay System. An IC50 of 206 nM for SIRT1 was obtained using a 12-point dose-response assay.
Selective SIRT1 inhibitor (IC50=206 nM). Does not inhibit other HDACs or SIRT family members. Increases p53 acetylation following DNA damage. EX-527 is a small molecule inhibitor of SIRT1 (Sirtuin 1), a member of the sirtuin family of proteins that play a critical role in regulating cellular processes like metabolism, aging, and stress resistance. SIRT1 acts as a NAD+-dependent deacetylase, which influences various cellular pathways, including gene expression, DNA repair, and inflammation.
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