BellBrook

SIRT1 (human) (rec.) (His) (active) (5µg)

As low as CHF 441.00

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BBL-2340-C0055 µgCHF 441.00

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Product Details
Synonyms	SIRT1; NAD-dependent Deacetylase Sirtuin-1; SIR2-like Protein 1; SIR2L1
Product Type	Protein
Properties
Source/Host	Insect cells
Sequence	Full-length human SIRT1 (aa 1-747) protein with a C-terminal His-tag.
Crossreactivity	Human
Application	Drug Discovery
Biological Activity	The enzyme has been thoroughly validated with the Transcreener OAADPr Assay Kit. Currently used with the Transcreener assay at a concentration of 3 nM in a 10 μL reaction.
MW	82.5kDa
Purity	≥85% (SDS-PAGE)
Accession Number	Q96EB6
Formulation	Liquid in 50 mM Tris, 500 mM NaCl, and 5% Glycerol (pH 8.0).
Other Product Data	Click here for Complete Information from the Original Manufacturer Our product description may differ slightly from the original manufacturer's product datasheet. Human SIRT1: Q96EB6
Shipping and Handling
Shipping	DRY ICE
Short Term Storage	-20°C
Long Term Storage	-80°C
Handling Advice	Avoid freeze/thaw cycles.
Use/Stability	Stable for at least 6 months after receipt when stored at -80°C.
Documents
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

Sirtuins (Silent information regulators; SIRTs) deacetylate and/or ADP-ribosylate lysine residues of target proteins in an NAD+-dependent manner. Sirtuins are critical regulators of many cellular processes, including insulin secretion, the cell cycle and apoptosis. Sirtuins, in particular SIRT1, emerged as critical regulators of longevity and aging in several model organisms. Furthermore, a variety of age-associated diseases such as type 2 diabetes, obesity, osteoporosis, and Alzheimer’s disease are associated with sirtuins. SIRT1 has been suggested as potential biomarker for tumorigenesis.

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