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BioViotica
Chalcomycin
130
CHF
CHF 130.00
In stock
BVT-0263-C500500 µgCHF 130.00
BVT-0263-M0011 mgCHF 215.00
| Product Details | |
|---|---|
| Synonyms | Aldgamycin D; NSC 150439 |
| Product Type | Chemical |
| Properties | |
| Formula |
C35H56O14 |
| MW | 700.8 |
| CAS | 20283-48-1 |
| Source/Host Chemicals | Isolated from Streptomyces bikiniensis. |
| Purity Chemicals | ≥96% (HPLC) |
| Appearance | Beige solid. |
| Solubility | Soluble in DMSO or acetone. |
| Identity | Determined by 1H-NMR and UV. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | KLGADJPDTCIJLO-GQVCZQSUSA-N |
| Smiles | CO[C@@H]1CC(C)O[C@@H](O[C@H]2[C@@H](C)C[C@](C)(O)C(=O)\C=C\[C@H]3O[C@H]3[C@H](CO[C@@H]3OC(C)[C@@H](O)[C@H](OC)C3OC)[C@@H](C)OC(=O)\C=C\[C@@H]2C)C1O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
- 16-membered macrolide antibiotic.
- Broad spectrum antimicrobial.
- Antibacterial and antifungal.
- Protein biosynthesis inhibitor.
Product References
- The structure of chalcomycin: P.W.K. Woo, et al.; JACS 86, 2726 (1964)
- Cross resistance pattern towards anticancer drugs of a human carcinoma multidrug-resistant cell line: R.S. Gupta, et al.; Br. J. Cancer 58, 441 (1988)
- Chalcomycin: single-crystal x-ray crystallographic analysis; biosynthetic and stereochemical correlations with other polyoxo macrolide antibiotics: P.W.K. Woo & J.R. Rubin; Tetrahedron 52, 3857 (1996)
- Chalcomycin B, a new macrolide antibiotic from the marine isolate Streptomyces sp. B7064: R.N. Asolkar, et al.; J. Antibiot. (Tokyo) 55, 893 (2002)
- Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: Novel features of an unusual ketolide produced through expression of the chm polyketide synthase in streptomyces fradiae: S.L. Ward, et al.; Antimicrob. Agents Chemoth. 48, 4703 (2004)
- Aldgamycin I, an antibacterial 16-membered macrolide from the abandoned mine bacterium, Streptomyces sp. KMA-001: J.-S. Park, et al.; J. Antibiot. (Tokyo) 62, 171 (2009)
- Imaging secondary metabolism of Streptomyces sp. Mg1 during cellular lysis and colony degradation of competing Bacillus subtilis: S.R. Barger, et al.; Antonie Van Leeuwenhoek 102, 435 (2012)
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