Nebularine (high purity)
BVT-0304-C500500 µgCHF 120.00
BVT-0304-M0011 mgCHF 190.00
|Synonyms||9-β-D-Ribofuranosyl-9H-purine; Purinosine; Ribosylpurine; NSC 65423; BRN 0091539|
|Source/Host Chemicals||Isolated from Streptomyces sp.|
|Purity Chemicals||≥98% (HPLC; NMR)|
|Appearance||White to off-white solid.|
|Solubility||Soluble in DMSO or methanol.|
|Identity||Determined by 1H-NMR.|
|Declaration||Manufactured by BioViotica.|
|Shipping and Handling|
|Short Term Storage||+4°C|
|Long Term Storage||-20°C|
|Handling Advice||Protect from light when in solution.|
Stable for at least 1 year after receipt when stored at -20°C.
Store solutions at -20°C in the dark.
|Product Specification Sheet|
- Nucleoside analog.
- Cytotoxic. DNA, RNA and protein synthesis inhibitor.
- Shows anticancer activity.
- Anti-mycobacterial. Has tuberculostatic activity.
- Antifungal activity.
- Antiviral (anti-Herpes).
- Adenosine deaminase inhibitor.
- Can be used to analyze structure determinants of DNA that are recognized by DNA repair enzymes, to locate triple helices at G-C sequences or as an universal base, which can bind to all four of the nucleosides of DNA.
- 9-β-D-ribofuranosylpurine from a Streptomycete: K. Isono & S. Suzuki; J. Antibiot. 13, 270 (1960)
- Structural requirements of nucleosides for binding by adenosine deaminase: J.G. Cory & R. Suhadolnik; Biochem. 4, 1729 (1965)
- Effects of purine riboside on nucleic acid synthesis in ascites cells: V. Bohr; Biochim. Biophys. Acta 519, 125 (1978)
- Treatment of mouse neoplasms with high doses of tubercidin: T.P. Lynch, et al.; Cancer Res. 41, 3200 (1981)
- Structure-activity relationship of ligands of human plasma adenosine deaminase 2: J.G. Niedzwicki & D.R. Abernethy; Biochem. Pharmacol. 41, 1615 (1991)
- Nebularine (9-2'-deoxy-beta-D-ribofuranosylpurine) has the template characteristics of adenine in vivo and in vitro: M.S Rahman & M.Z. Humayun; Mutat. Res. 377, 263 (1997)
- Virtual combinatorial syntheses and computational screening of new potential anti-herpes compounds: J.V. de Julian-Ortiz, et al.; J. Med. Chem. 42, 3308 (1999)
- Synthesis and stability of GNRA-loop analogs: K. Worner, et al.; Helv. Chim. Acta 82, 2094 (1999)
- Chemical constituents of the fruiting bodies of Clitocybe nebularis and their antifungal activity: Y.-S. Kim, et al.; Mycobiol. 36,110 (2008)
- Investigations into the origin of the molecular recognition of several adenosine deaminase inhibitors: I. Gillerman & B. Fischer; J. Med. Chem. 54, 107 (2011)