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Chemodex
Amikacin hydrate
122
CHF
CHF 122.00
In stock
CDX-A0287-G0055 gCHF 122.00
| Product Details | |
|---|---|
| Synonyms | N1-[(S)-4-Amino-2-hydroxybutyryl]kanamycin A; Amicacin; Amikacillin; Amukin; Antibiotic BB-K 8; BAY 41-6551; BAY 416651 |
| Product Type | Chemical |
| Properties | |
| Formula |
C22H43N5O13 . xH2O |
| MW | 585.60 (anhydrous basis) |
| CAS | 1257517-67-1 | 37517-28-5 (anhydrous) |
| RTECS | WK1955000 |
| Source/Host Chemicals | Semisynthetic |
| Purity Chemicals | ≥97% (NMR) |
| Appearance | White crystalline powder. |
| Solubility | Soluble in water (10mg/ml). |
| Identity | Determined by NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | LKCWBDHBTVXHDL-RMDFUYIESA-N |
| Smiles | O[C@@H]1[C@@H](CN)O[C@H](O[C@H]2[C@H](O)[C@@H](O[C@@H]3[C@H](O)[C@@H](N)[C@H](O)[C@@H](CO)O3)[C@H](NC([C@H](CCN)O)=O)C[C@@H]2N)[C@H](O)[C@H]1O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Description
Broad-spectrum semisynthetic aminoglycoside antibiotic derived from kanamycin A, which is effective against Gram-negative and Gram-positive bacteria. Aminoglycoside antibiotics bind the 30s ribosomal subunit, causing misreading of the mRNA sequence and inhibition of translocation, consequently inhibiting bacterial protein synthesis. Commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (ASTs, panels, discs, and MIC strips) of organisms such as Mycobacterium tuberculosis and Ehrlichia phagocytophila.
Product References
(1) H. Kawaguchi, et al.; J. Antibiot. 25, 695 (1972) | (2) K.E. Price, et al.; Antimicrob. Agents Chemother. 5, 143 (1974) | (3) N.S. Brewer; Mayo Clin. Proc. 52, 675 (1977) | (4) R.N. Jones, et al.; Antimicrob. Agents Chemother. 22, 985 (1982) | (5) A.M. Ristuccia & B.A. Cunha; Ther. Drug Monit. 7, 12 (1985) | (6) B.D. Davis; Microbiol. Rev. 51, 341 (1987) | (7) B.A. Cunha; Med. Clin. North Am. 90, 1089 (2006) | (8) M.S. Ramirez & M.E. Tolmasky; Molecules 22, E2267 (2017)