3-Carboxy-6,8-difluoro-7-hydroxycoumarin

Specifications / Handling

More Information
Product Details
Synonyms	NHS Pacific Blue succinimidyl ester; Ocean Blue succinimidyl ester; 2,5-Dioxopyrrolidin-1-yl 6,8-difluoro-7-hydroxy-2-oxo-2H-chromene-3-carboxylate
Product Type	Chemical
Properties
Formula	C₁₄H₇F₂NO₇
MW	339.2
CAS	215868-33-0
Source/Host Chemicals	Synthetic.
Purity Chemicals	≥98% (HPLC)
Appearance	Yellow powder.
Solubility	Soluble in chloroform.
Identity	Determined by NMR.
Declaration	Manufactured by Chemodex.
Other Product Data	Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet.
InChi Key	NZYXABPVYJRICY-UHFFFAOYSA-N
Smiles	OC1=C(F)C2=C(C=C1F)C=C(C(=O)ON1C(=O)CCC1=O)C(=O)O2
Shipping and Handling
Shipping	AMBIENT
Short Term Storage	+4°C
Long Term Storage	-20°C
Handling Advice	Keep cool and dry. Protect from light and moisture.
Use/Stability	Stable for at least 2 years after receipt when stored at -20°C.
Documents
MSDS	Download PDF
Product Specification Sheet
Datasheet	Download PDF

Product-specific References

Description

This amine-reactive reagent can be used to create blue-fluorescent bioconjugates with excitation/emission maxima ~410/455 nm that are excitable by the 405 nm spectral line of the blue diode (violet) laser. Used in highly sensitive analyses of amines, amino acids and dipeptides. Amine-reactive reagents react with non-protonated aliphatic amine groups, including the amine terminus of proteins and the є-amino group of lysines.

Product References

(1) B. Abrams, et al.; Anal. Biochem. 386, 262 (2009) | (2) T.N. Chiesl, et al.; Anal. Chem. 81, 2537 (2009) | (3) J.D. Cohen, et al.; Biochem. 50, 8221 (2011) | (4) A.M. Stockton, et al.; Dyes & Pigments 96, 148 (2013)

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