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Chemodex
Domperidone
102
CHF
CHF 102.00
In stock
CDX-D0809-M100100 mgCHF 102.00
CDX-D0809-M500500 mgCHF 407.00
| Product Details | |
|---|---|
| Synonyms | R33812; 4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-[3-(2-oxobenzimidazolinyl)propyl]piperidine; Motilium; NSC 299589 |
| Product Type | Chemical |
| Properties | |
| Formula |
C22H24ClN5O2 |
| MW | 425.91 |
| CAS | 57808-66-9 |
| RTECS | DE2275900 |
| Source/Host Chemicals | Synthetic. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White powder. |
| Solubility | Soluble in DMSO (10mg/ml). |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by Chemodex. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet |
| InChi Key | FGXWKSZFVQUSTL-UHFFFAOYSA-N |
| Smiles | ClC1=CC(NC2=O)=C(C=C1)N2C(CC3)CCN3CCCN(C4=CC=CC=C4N5)C5=O |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS | Inquire |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Description
Domperidone is a peripheral dopamine D2-like receptor antagonist that does not readily cross the blood-brain barrier. It demonstrates a potent affinity for the rat D2 receptor and is also reported to inhibit the rat D3 receptor. The antidopaminergic effects are cross-realted to its gastroprokinetic and antiemetic properties.
Product References
(1) D.B. Wilson & J.W. Dundee; Anaesthesia 34, 765 (1979) | (2) C.J. Niemegeers, et al.; Arch. Int. Pharmacodyn. Ther. 244, 130 (1980) | (3) M.C. Champion, et al.; Can. Med. Assoc. J. 135, 457 (1986) | (4) C. Lin, et al.; J. Pharmacol. Exper. Therap. 242, 950 (1987) | (5) P. Sokoloff, et al.; Nature 137, 146 (1990) | (6) A. Prakash & A.J. Wagstaff; Drugs 56, 429 (1998) | (7) Y. Hirokawa, et al.; J. Med. Chem. 46, 702 (2003) | (8) M.A. Osinski, et al.; Pharmacol. Biochem. Behav. 81, 211 (2005)